J. Huang

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

The paper analyzes RNA-seq and scRNA-seq datasets to identify immune cell interactions in the testicular microenvironment of azoospermia patients, finding altered monocyte/macrophage signaling patterns.

This study shows that the ESCRT pathway and MVBs are essential for trap formation in the nematode-trapping fungus Arthrobotrys oligospora in response to ammonia.

This paper investigates cytostatic hypothermia as a therapeutic approach for glioblastoma, showing it extends survival in rodent models by halting tumor growth without chemical interventions.

This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.

This study identifies a signaling cascade involving GxcM, Fbp17, RacC, and WASP that regulates rear cortical actin assembly in migrating Dictyostelium cells.

This study shows that temporarily knocking down p53 during radiation therapy increases the risk of sarcoma development in mice.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

The paper investigates how sub-threshold odor mixtures mask the unpleasant smell of iso-valeric acid using Sniff Olfactometry, finding that mixtures reduce recognition by up to 96%.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

This study shows that nicotinamide riboside improves exercise capacity in ANT1-deficient mice by increasing NAD+ levels and mitochondrial respiration.

This study identifies ZNF251 haploinsufficiency as a mechanism conferring PARP inhibitor resistance in BRCA1-mutated cancer cells through RAD51-mediated homologous recombination.

This study shows that senescence in CD8+ T cells reduces VLA-4 expression, impairing their migration and promoting leptomeningeal metastasis in a mouse model of breast cancer.

This paper develops an amplified lateral flow assay for at-home SARS-CoV-2 testing with improved sensitivity compared to commercial assays.

This paper develops a visual perception system using pose estimation to analyze fish swimming and provides code and dataset for the method.

The paper identifies parallel amino acid substitutions at the Rdl gene in insect pests and their parasitoid wasps, showing how resistance to insecticides evolves in both species.

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

The paper analyzes marmoset monkey vocalizations to show that call patterns encode emotional states and transmit emotion between individuals.

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

This study demonstrates the durable engraftment of PSC-derived lung epithelial cells into immunocompetent mice, showing long-term retention of both progenitor and differentiated cell phenotypes.

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

This paper shows that ascorbic acid-derived carbon dots (VCDs) improve circadian rhythm and reduce hyperactive behavior in a zebrafish ADHD model caused by per1b mutation.

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

PeerPub enables multiple rats to self-administer solutions concurrently, showing increased consumption in group housing compared to isolation.