J. Huang

This study investigates enrofloxacin's ability to cross the blood-brain barrier in crucian carp and its impact on brain injury markers.

This study designs and tests a chimeric fusion protein vaccine (RHMS-1) combining immunodominant epitopes from RSV and hMPV F proteins, showing protection against both viruses in mice.

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study shows IDH3B is essential for spermiogenesis but not retinal health, as Idh3b-knockout mice are infertile but have normal vision.

This study compares the transcriptomes of primary, cultured, and iPSC-derived human alveolar type 2 cells to assess how culture affects their gene expression profiles and maturation states.

The paper shows that nitazoxanide inhibits SARS-CoV-2 replication and pathogenesis in human and hamster models, and synergizes with remdesivir against multiple variants.

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

This study compares slow-cycling cells with cancer stem cell (CSC)-like cells in glioblastoma, showing phenotypic and functional heterogeneity and supporting the cancer stem cell mosaicism model.

This study builds a 22-gene prognosis model for hepatocellular carcinoma using pyroptosis-related signatures, showing low-risk patients have significantly better survival.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

The paper identifies tuftsin as a natural human molecule that targets ACE2 and NRP1, impairing SARS-CoV-2 infection and suggesting its potential as a therapeutic for COVID-19.

This study identifies two snoRNA-derived fragments, sdRNA-D19b and sdRNA-A24, that promote castration-resistant prostate cancer by downregulating tumor suppressors and conferring drug resistance.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

CHARM study examines T cell responses in asymptomatic and symptomatic SARS-CoV-2 infected Marines, finding persistent IFN-gamma responses to S, N, and M proteins, with higher frequencies to N in asymptomatic cases.

This study investigates whether COVID-19 mRNA vaccination affects pregnancy outcomes or induces anti-syncytin-1 antibodies, finding no evidence of fetal defects or increased antibody levels.

This study identifies tRNA fragments (tRFs) in Salmonella OMVs that inhibit bacteriophage P22 infection, showing their role in antiviral defense.

This study shows that progestin receptors regulate coagulation factors during ovulation in zebrafish, linking blood clotting to the ovulation process.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The paper investigates paradoxical activation of RAF kinases, showing that 14-3-3 proteins enhance this effect by stabilizing RAF conformations and dimerization.

This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

The paper investigates DNA repair mechanisms after CRISPR-Cas12a-induced double-strand breaks in Magnaporthe oryzae, identifying locus-dependent and error-prone repair pathways leading to various mutation types.

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

The paper identifies three new folds in the solute carrier superfamily, with one validated experimentally in the SLC44 family, providing insights into structure-function relationships.

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.