J. Wang

This study identifies PBP2 as the primary target of cephalosporins in C. difficile and reveals a unique Zn2+-binding motif in PBP2 and related PBPs that contributes to cephalosporin resistance and sporulation.

The paper shows that parasite-induced limb movements in male frogs enhance the attractiveness of acoustic signals by incorporating visual elements, influencing female mate choice.

The paper determines the high-resolution structure of MgtE TM domain with Ca2+ and shows Mg2+ binds 500-fold stronger than Ca2+.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study examines microbiome changes in lung and gut of NSCLC patients and finds sputum microbiota better predicts disease and metastasis than gut microbiota, with machine learning models achieving 0.842 AUC.

The paper introduces TRAPS-seq, a method to measure single-cell protein secretion, phenotypes, and transcriptomes, revealing limited correlation between cytokine secretion and transcript abundance in T cells.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study identifies PDK1 as a driver of osimertinib resistance in NSCLC, showing its inhibition sensitizes resistant cells and correlates with disease progression.

This study uses single-molecule techniques and cryo-EM to show how eIF1A and eIF5B remodel initiation complexes to facilitate ribosomal subunit joining during translation initiation.

The paper uses single-cell RNA sequencing to analyze T cell responses in mice infected with E. multilocularis, revealing distinct interactions between regulatory T and natural killer T cells that influence disease progression.

The paper directly observes yeast 43S ribosomal scanning along mRNA 5'UTRs, revealing its speed and structural regulation mechanisms.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

The paper identifies and validates 25 putative genomic safe harbour loci for transgene integration in human cells using computational analysis and in vitro experiments.

This study shows Salmonella chitinases enhance intestinal invasion by modulating host glycans, with chitinase-deficient strains showing reduced invasion and delayed dissemination.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

This study identifies tropifexor as a potent SARS-CoV-2 PLpro inhibitor through drug repurposing screening, showing antiviral activity in Calu-3 cells.

This paper develops a vascular bundle detection model for Phyllostachys and finds consistent radial gradient patterns across 29 species.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

This study investigates mitotic outcomes in fibrous environments by analyzing how cell shape, adhesion geometry, and fiber arrangement affect mitotic stability and division dynamics.

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

This paper introduces two deep learning methods for designing proteins with specific functional sites, showing they can generate diverse proteins with desired properties.

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

The paper validates or invalidates reported SARS-CoV-2 PLpro inhibitors using enzymatic, thermal shift, and cell-based assays, finding most compounds lack binding or cellular inhibition.

The paper uses AlphaFold models to predict protein structures for understudied human proteins, finding that 95% of models with confidence scores above 80 are accurate at the fold level.