J. Xu

APEX-seq maps subcellular RNA localization with nanometer resolution, revealing nuclear transcriptome organization and mitochondrial mRNA pathways.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

This study shows pretomanid improves the efficacy of TB treatment regimens in mice by reducing relapse and bedaquiline resistance.

The paper shows hypotonic stress causes rapid, reversible vimentin cytoskeleton degradation via calcium release and calpain proteolysis, preceding changes in other cytoskeletal systems.

The study detects Wolbachia in wild Ae. aegypti mosquitoes from New Mexico and Florida, but not in Texas, and identifies the wAlbB strain.

This study examines how fungal communities in soil change along a forest disturbance gradient, finding declines in saprotrophic fungi and increases in pathogenic fungi, indicating shifts in soil nutrient limitations.

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

The paper uses simulations to show cargo diffusion reduces single-kinesin run length, with effects influenced by viscous drag and load direction.

This paper introduces dRenSeq, a method to track disease resistance genes in potato breeding, enabling efficient validation and monitoring of resistance gene integrity.

The paper investigates how de novo microRNAs in Drosophila affect male fitness and reveals that adaptive de novo genes may die due to canceling fitness effects, suggesting quasi-neutrality and ongoing period-specific adaptations.

This paper develops a live attenuated S. suis vaccine by deleting multiple virulence genes, showing it suppresses STSLS and provides ST-independent protection in mice.

This study identifies mercury methylating microbial communities in boreal forest soils using 16S rRNA and hgcA sequencing, revealing diverse taxa and non-methylating bacteria contributing to methylmercury formation.

This study shows PIP5K1β regulates bone homeostasis by modulating osteoclast and osteoblast differentiation through multiple signaling pathways.

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

This study investigates the genomic features and evolution of a conditionally dispensable chromosome (CDC) in the tangerine pathotype of Alternaria alternata, revealing its role in pathogenicity and horizontal gene transfer.

This study compares gentle and harsh touch responses in C. elegans using a microfluidic device, finding differences in receptive fields and response dependencies.

This study shows replication defective viral genomes (DVGs) protect certain cells from death and promote viral persistence by activating a TNF-mediated survival pathway during infection.

The paper investigates RFO metabolism in cucumber leaves under cold stress and recovery, showing compartment-specific accumulation and catabolism by galactosidases.

The paper reports the crystal structure of the YTH domain of Mmi1 bound to DSR-containing RNA, revealing the mechanism of specific RNA recognition and its distinct function compared to other YTH domain proteins.

This paper traces the evolutionary history of the miR390-TAS3-ARF pathway across land plants, showing its conservation and diversification in regulatory mechanisms.

This study shows that 14-3-3 negatively regulates actin filament formation in Giardia lamblia by interacting with actin and modulating its phosphorylation state.