J. Zhang

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

This study identifies that the tetrapeptide sequence of IL-1β regulates its cleavage by non-canonical inflammasomes, revealing a mechanism for inflammation control.

This study compares pollutant exposure, health, and survival of migratory shorebirds in natural and artificial wetlands, finding negligible differences and suggesting wastewater treatment plants could serve as viable habitats.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.

The paper presents crystal structures of cis-acyltransferase (cis-AT) modular polyketide synthases (PKSs) to elucidate domain-domain interactions and reaction chamber organization.

This study shows that MGA deletion drives Richter's transformation by modulating mitochondrial OXPHOS through the MGA-NME1 axis, suggesting a new therapeutic target.

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

This study identifies three novel chuviruses as the cause of lymphocytic meningoencephalomyelitis in three aquatic turtles, providing the first in situ evidence of chuviral pathogenicity in animals.

This paper identifies LXY18, a 4-phenoxy-quinoline compound that blocks AURKB relocalization, showing potent antimitotic activity and oral bioavailability.

This study shows Yersinia pseudotuberculosis effectors evade the caspase-4 inflammasome in human cells, unlike in mouse macrophages, by inhibiting Yersinia internalization.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

The paper presents the cryo-EM structure of BoNT/X-NTNH/X complex and shows its stability and low potency due to weak receptor-binding properties.

This paper identifies and characterizes the gene PLATZ-A1 underlying the GA-sensitive dwarfing locus RHT25 in wheat, showing it interacts with RHT1 and can modulate plant height.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

The paper examines spatial patterns of PAG activity and physiological responses during social stress in humans using 7T imaging.

This study optimizes dMRI tractography for reliable reconstruction of the mouse brain thalamocortical network by evaluating imaging and tractography parameters using an atlas and tracer data.

This study analyzes land use changes and driving factors in Putian City from 2000 to 2020 using remote sensing data and statistical methods.

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

This study shows that pdm09 H1N1 influenza viruses from humans can persist in swine, evolve, and transmit back to humans, increasing pandemic risk.

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

This study identifies disruption of the nuclear localization signal in RBM20 as a causative mechanism in dilated cardiomyopathy through impaired nucleocytoplasmic transport.

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.