J. Zhu

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.

This study shows that GIT1 and β-Pix form a condensed enzyme complex via phase separation, enabling compartmentalized signaling in different cellular contexts.

This study computationally screens mechanical forces in multi-centrosomal cells to determine conditions for bipolar spindle assembly and identifies configurations for abnormal spindles.

The paper shows that InsP8 binds to SPX domains, altering PHR transcription factors' oligomeric state and DNA binding, thus regulating phosphate homeostasis in plants.

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

The paper develops a DNA-based data storage system using Watson-Crick base pairing for secure, rewritable data storage on DNA hard drives.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

The paper assembles over 56,000 metagenome-assembled genomes from oral microbiome samples, revealing new taxa and biomarkers for diseases.

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

This paper introduces an automated data labeling neural network for real-time hand motion prediction from sEMG signals, achieving high accuracy and early response with no need for manual motion labeling.

This study shows collagen I weakly interacts with β2-microglobulin, promoting conformational exchange that leads to amyloid formation.

This paper introduces a single-molecule Gq nanopore assay to detect G-quadruplexes and their folding kinetics without fluorescent labels.

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

The paper describes the UCSC Xena platform, which enables secure visualization and analysis of both public and private cancer genomics data through web-based tools and hubs.

The paper identifies diverse flanking sequences of blaNDM in specific plasmids from E. coli isolated from poultry, highlighting the role of IS26 in plasmid evolution.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

The paper shows that Syntrophus aciditrophicus can use direct interspecies electron transfer via conductive pili, challenging the belief that hydrogen/formate transfer is the primary mechanism in syntrophic communities.

This study identifies MUC5AC as a driver of COPD exacerbation severity by amplifying virus-induced airway inflammation through ATP release.

This study identifies two distinct LUSC subtypes driven by Sox2 partnerships with Brn2 or p63, revealing lineage heterogeneity and potential therapeutic targets.

This study tracks the development of a potent ZIKV-specific antibody in a convalescent human, revealing limited somatic hypermutation and high germline identity.

The paper develops a method to detect inorganic polyphosphates in plants using a dye and binding domain, finding that higher plants lack large polyP stores.

This paper introduces a scalable method for inferring phylogenetic networks from multi-locus data, achieving accurate results at a larger scale than existing methods.

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

This study identifies CHAD domains as specific inorganic polyphosphate binding modules across bacteria, archaea, and eukaryotes, revealing their structural and functional roles in polyP metabolism and localization.

This study identifies VIH1 and VIH2 as bifunctional enzymes regulating phosphate homeostasis in Arabidopsis by modulating PP-InsP levels in response to ATP concentration changes.

This study shows that indole pulses in E. coli regulate cytoplasmic pH in a memory-like manner, maintaining pH at 7.2 during stationary phase and protecting against stress.

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

This paper demonstrates that gp41ECTO is the main source of HIV-1 envelope metastability and shows that stabilizing it improves nanoparticle assembly and induces more effective tier 2 neutralizing antibodies.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.