L. Wu

This study examines how different metabolic environments affect three cancer cell phenotypes: drug survival, migration, and lactate overflow, revealing quantitative relationships between metabolism and cell behavior.

The paper investigates how synergistic epistasis enhances cooperativity in mutualistic interspecies interactions between Desulfovibrio vulgaris and Methanococcus maripaludis under varying sulfate conditions.

This study shows that targeting Gpi1 selectively inhibits pathogenic Th17 cells in autoimmune diseases while sparing homeostatic Th17 cells.

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

The paper analyzes CD45 isoforms in T cells from liver cancer patients to show their role in T cell heterogeneity and function.

This study identifies convergent genetic and physiological adaptations in multiple fish lineages that enable tolerance to hydrogen sulfide, showing that conserved mitochondrial pathways are repeatedly modified for H2S resistance.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

This study reports the crystal structure of the N-terminal domain of DdMCU and shows its oligomeric state and calcium-dependent dissociation.

Inhibiting the prostaglandin transporter PGT reduces body fat and induces UCP1-independent thermogenesis in mice on a high-fat diet.

This study evaluates rice wild relatives for traits to improve adaptation to iron toxicity and grain quality, finding some genotypes perform better than domesticated rice in specific stress conditions.

The paper identifies distinct ligand-directed plasma membrane signalsomes in Arabidopsis that drive biased signaling through compartmentation and different trafficking origins.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This paper introduces an AI model to design and fold alpha-helical proteins from amino acid sequences, achieving high accuracy and efficiency.

The paper shows that the RNF43-G659Vfs41 mutation is functional and not a driver mutation in tumorigenesis, but may be a passenger mutation in MLH1-downregulated tumors.

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.

This study uses single-particle tracking to show that KRas diffusion and trafficking are regulated by nested membrane nanodomains in U2OS cells.

This study identifies IL-10-producing B cells in murine pericardial adipose tissues that promote cardiac recovery after acute myocardial infarction by resolving inflammation and reducing myocardial injury.

This study identifies two bile acid metabolites that regulate Th17 and Treg cell differentiation through distinct mechanisms, affecting immune balance in mice.

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

This study investigates the effect of L. reuteri on immune parameters and gut microbiota, revealing sex-specific differences in immune response and microbial composition.

This study shows YTHDF1-3 proteins inhibit HIV-1 infection by binding m6A-modified viral RNA, reducing reverse transcription and viral production.

This study shows that SAMHD1 suppresses HIV-1 gene expression and reactivation in CD4+ T-cells by binding to the HIV-1 LTR and inhibiting transcription.

The paper develops and validates a new red fluorescent calcium indicator, K-GECO1, based on a circularly permutated RFP from a sea anemone, tested across multiple cell types and organisms.

This study determines the first crystal structure of full-length mouse SAMHD1 in three nucleotide-bound states, revealing a more complex activation process involving the SAM domain compared to human SAMHD1.

This study shows asbestos exposure triggers YAP/TAZ activation, macrophage recruitment, and RNA editing in mesothelium before tumor development.

The paper predicts DNA hybridization rate constants from sequence using a weighted neighbor voting model trained on experimental kinetics data.