L. Wu

This study shows HDAC3 is essential for pDC development and hematopoietic progenitor homeostasis, with HDAC3 repressing cDC1-associated genes to promote pDC differentiation.

This study shows that FBXO11 deficiency in mice leads to impaired lung development and worsens cigarette smoke-induced airway fibrosis by promoting epithelial-mesenchymal transition.

This study shows that existing microbial source tracking solvers fail to solve the MST problem when ecological dynamics, such as microbial interactions and priority effects, are present.

DINAVID provides a cloud-based system for remote 3D microscopy image analysis and visualization, designed to handle large datasets and improve accessibility.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This paper introduces EMR-CNN, a 3D nuclei segmentation method that avoids ground truth annotations and uses ensemble learning and slice fusion for efficient and accurate results.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study identifies key genes regulating mesophyll conductance in drought-resistant rice under severe drought by comparing gene expression and photosynthetic processes between two rice cultivars.

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

This study evaluates the anti-tumor activities of 25 sulfonylurea derivatives in breast carcinoma cell lines, finding concentration- and time-dependent inhibitory effects on cell growth, proliferation, migration, and survival.

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study identifies Arkadia-SKI/SnoN signaling as a regulator of TGF-β-induced iTreg differentiation, distinct from Th17 cell differentiation.

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

This study examines how dietary fiber affects gut microbiome dynamics and SCFAs in mice, showing baseline-dependent responses and the importance of ecological modeling.

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

This study shows emerin forms oligomeric nanoclusters at the nuclear envelope, which regulate nuclear shape and mechanics under stress, and that mutations in emerin disrupt this process, leading to nuclear deformations in EDMD.

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

The paper investigates the evolutionary origin of decidual cells by comparing mesenchymal-epithelial transition and fibroblast activation models, finding support for the latter through transcriptomic analysis.

This study shows ROR is essential for maintaining Th17 cell effector function through cooperative binding with ROR{gamma}t to an enhancer element.

This study identifies rosmarinic acid as a potent inhibitor of amylin aggregation and shows its efficacy in reducing amyloid deposits and mitigating diabetic pathology in HIP rats.

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This study identifies TRAF6 and TAK1 as mediators of SAMHD1's suppression of NF-κB activation and HIV-1 infection.

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.

The paper uses single-cell multi-omics to analyze HCC cell lines, identifying metastasis potential heterogeneity and a hypoxic subgroup with poor prognosis.