P. Li

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This paper introduces a high-throughput drug screening method called CEBIT that detects biomolecular interactions and enzyme inhibitors by using phase-separated compartments.

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

This study introduces DeRetro, a deep learning framework for retrosynthesis that improves performance and explainability by decomposing the task into reactive center prediction and molecule generation.

This study identifies transcriptional changes in peanut seeds during dormancy release and germination, revealing key pathways and hormone-related genes involved in these processes.

This study identifies human lncRNA metabolic regulators (hLMRs) using integrative transcriptome analyses and humanized mouse models, validating one hLMR's role in cholesterol metabolism.

The paper introduces PACPIC, a method using phase separation to identify direct and indirect protein-protein interactions in cells by recruitment as a readout.

This study compares two Andean frog species to test vicariance versus elevational gradient models of diversification, finding support for vicariance but differing divergence times between species.

This study identifies 53 QTLs associated with Verticillium wilt resistance in cotton using CSSLs and detects 32 novel QTL hotspot regions, providing a foundation for genetic analysis and breeding programs.

This study identifies PsaE's role in regulating psaA in Yersinia pestis, showing its temperature- and pH-dependent expression and binding sites across the genome.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

This study shows that P16 methylation increases cancer cell sensitivity to palbociclib, a CDK4/6 inhibitor, through experimental and pharmacogenomic analyses.

This study uses in silico cardiac cell models to evaluate drug-induced arrhythmogenic risks by analyzing transmural and rate-dependent effects of multichannel inhibition.

This study identifies E-cadherin as a facilitator of HBV entry by interacting with glycosylated NTCP and regulating hepatocyte polarity.

This study uses CFD simulations to analyze how oral appliances alter upper airway morphology and airflow dynamics in OSAHS patients, showing reduced resistance and improved patency.

The paper describes improvements to the GigaScience Database, GigaDB, focusing on enhanced interactivity and functionality based on user metrics and platform overhauls.

This study identifies molecular mechanisms of shade responses in maize by analyzing transcriptome changes and functionally testing a key transcription factor.

This paper develops a smartphone-based retinal imaging system with automation features, showing it can generate high-quality wide-field retinal images for disease screening.

The paper demonstrates that SHR and stele-derived small peptides coordinate to rebuild functional Casparian strips in non-endodermal cells through two parallel signaling systems.