P. Li

This study identifies circMRPS35 as a factor promoting HCC progression and cisplatin resistance through miR-148a-3p sponging and a drug-induced peptide.

This paper shows hydrophobic-cationic peptides enhance RNA polymerase ribozyme activity by concentrating RNA, with effects dependent on magnesium ion concentration.

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

The paper assesses amino acid and amine stability in human serum under various preprocessing and storage conditions using iTRAQ(R)-LC-MS/MS.

This study identifies EZH2's role in promoting breast cancer bone metastasis through the integrin β1-FAK pathway and TGFβ signaling.

This study identifies novel regulatory modules involving ZmBEH1 and ZmBZR1 that control leaf angle in maize, offering new gene editing targets for improving plant architecture.

This study shows that nitrate signaling suppresses the low R:FR-induced reduction of lateral root growth in Arabidopsis, involving HY5 and NRT2.1.

This study shows that glycolysis fuels PI3K signaling in CD8+ T cells, linking metabolic reprogramming to T cell immunity and suggesting therapeutic targets for infectious diseases and cancer.

The paper identifies binary and ternary protein interactions among SARS-CoV-2 replication/transcription complex components using a novel compartmentalization-based screening method.

This study compares three porcine corneal decellularization methods and shows that preserving the limbus reduces decellularization efficiency but lessens structural damage.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

The paper examines changes in plasmodesma structure and permeability during maize C4 leaf development, finding that plasmodesmata remodeling and transport restriction are accelerated in C4 pathway mutants.

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The paper models conformational changes in the full-length insulin receptor during activation, identifying two possible transition pathways and analyzing domain motions.

The paper sequenced genomes of Pneumocystis species from different mammals to study host specificity and evolutionary adaptations, revealing insights into the emergence of the human pathogen P. jirovecii.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.

This study identifies TRIM14 as a negative regulator of the type I interferon response in macrophages during Mycobacterium tuberculosis infection, showing it enhances resolution of the response and limits bacterial replication.

The paper estimates the germline mutation rate in rhesus macaques and finds paternal age correlation, male contribution dominance, and divergence time implications for primate phylogeny.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study investigates the diversity anomaly of Heterotropa in insular versus continental regions by analyzing phylogenetic relationships and floral trait evolution.

This study develops and evaluates porous scaffolds combining HA, PLGA, and MSM for bone defect reconstruction, showing improved cell adhesion, proliferation, and drug release properties.

This study shows that maternal vitamin D deficiency increases obesity risk in male offspring by altering immune responses and adipose tissue inflammation.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.

The rab8d-dependent plastid signal mediated by ATM and GUN1 regulates the root meristem size and renewal of root stem cells, respectively.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.