P. Liu

This study shows low light stress reduces summer maize yield by decreasing leaf photosynthetic rate, impairing sucrose transport to grains, and creating a sugar concentration gradient that inhibits sucrose output.

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This study shows colony size can measure fitness in yeast as effectively as liquid culture assays, after accounting for edge effects.

The paper identifies a Bcl11a/Bcl6-dependent pathway that regulates developmental cell death in cortical projection neurons during corticogenesis.

This paper develops a bispecific antibody that targets both RBD and S2 of SARS-CoV-2, showing improved neutralization against Omicron and other variants compared to its parental monoclonal antibodies.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

The paper studies thermophoresis of various biomolecules in self-assembled matrices, showing enhanced thermodiffusion due to surrounding network effects.

The paper identifies YAB11-NGAL1 as a regulator of leaf serration in poplar through GWAS and eQTN mapping, showing its role in environmental adaptation and morphological plasticity.

The paper investigates the role of circadian clocks in liver and skeletal muscle in glucose metabolism, finding that inter-organ communication is necessary for systemic glucose homeostasis.

The paper identifies hpm91, a Chlamydomonas mutant with high hydrogen production, as scalable and robust for large-scale algal H2 photoproduction.

This study uses CRISPR to correct dystrophin mutations in DMD patient-derived PSCs, revealing impaired Ca2+ handling and showing rescue through gene correction.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

OrganoID automatically tracks and analyzes single-organoid dynamics in microscopy images, showing high accuracy in counting, sizing, and morphology analysis across multiple organoid types.

This paper develops an engineered A549 cell model overexpressing ACE2 and TMPRSS2 to study SARS-CoV-2 infection and antiviral responses.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

The paper uses stem cell-derived macrophages from livestock to study host-pathogen interactions, showing they can be infected by important viruses and genetically modified.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

The paper introduces a universal microfluidic method for studying bacterial biofilms, demonstrating insights into H2O2 resistance and resource retention mechanisms in E. coli and P. aeruginosa biofilms.

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

The paper identifies immunosuppressive signatures and functional maturity of fetal immune cells in human placental villi across gestational ages.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

The paper identifies beneficial and detrimental bacteria affecting sorghum drought responses using lab, transitional, and field experiments.

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

This study quantifies the funny current (If) in murine sinoatrial node myocytes, showing its persistent activity and dual role in driving membrane potential oscillations during pacemaking.