P. Wang

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

The paper develops a cell type-specific multiomics pipeline to analyze guard cells and mesophyll cells, revealing a kinase cascade involved in ABA-induced stomatal closure.

This study detects SARS-CoV-2 RNA in immune cells of mice using RNA-FISH and FLSM, showing early dissemination of the virus in blood.

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

The paper investigates miR-384's role in regulating Reelin by inhibiting ADAMTS4 in neuronal cell lines, showing reduced ADAMTS4 and Reelin fragments with miR-384 overexpression.

This study examines the correlation between vaccine-induced IgG levels and neutralizing titers against SARS-CoV-2 and its variants, finding a significant positive correlation and reduced neutralization against variants.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This study identifies TIC236 gain-of-function mutations that enhance plastid protein import and reveal their role in plastid division and plant stress response.

This study shows that the B.1.1.7 SARS-CoV-2 variant replicates and sheds more efficiently in hamsters' nasal cavities than earlier D614G variants with lower doses and shorter exposure.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

This study shows the SARS-CoV-2 P.1 variant is more resistant to antibody neutralization than previous variants, but less affected by vaccine-induced immunity.

The paper identifies a 32-gene signature specific to Ewing sarcoma and shows that LOXHD1, a stereociliary protein, is a key driver of malignancy through its regulation by EWSR1-FLI1.

This study reports cryo-EM structures of two SARS-CoV-2 neutralizing antibodies bound to spike proteins of emerging variants, showing they retain potency despite RBD mutations.

This paper develops and validates a mouse model of cannabis smoke exposure, showing changes in immune cell populations and mediators in both male and female mice.

This study investigates the roles of RIG-I and MDA5 in SARS-CoV-2 infection, finding that MDA5 is critical for type I/III IFN response while RIG-I has an IFN-independent antiviral effect.

This study identifies SPX1 and SPX3 as regulators of phosphate homeostasis, mycorrhizal colonization, and arbuscule degradation in Medicago truncatula.

This study shows that GS-441524, a metabolite of remdesivir, effectively inhibits SARS-CoV-2 in cell cultures and mice, suggesting it may contribute to remdesivir's antiviral activity.

The paper identifies IRP as a DAMP in rice immunity, showing it activates MAPKs and OsWRKYs to amplify chitin signaling.

The paper identifies MIK2 as a plant receptor that recognizes conserved peptide motifs from phytocytokines and microbial proteins, triggering immune responses through a signaling relay.

This study evaluates the neutralization resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to monoclonal antibodies and sera, finding increased resistance in B.1.351.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

The paper determines structures of three VH1-2-derived antibodies in complex with SARS-CoV-2 spike, revealing modular recognition mechanisms and conformational changes.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.