P. Wang

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

The paper identifies a novel ATP-dependent DMSP lysis pathway in bacteria, revealing a new route in the marine sulfur cycle through the enzyme AcoD.

This study uses single-cell RNA sequencing to identify silkworm hemocyte subsets and analyze their response to BmNPV infection, revealing diverse gene expression changes and immune suppression.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

This paper develops a LAMP assay for rapid detection of the nirS gene in denitrifying bacteria, showing high specificity and sensitivity compared to conventional PCR.

This study finds that patients with severe SARS-CoV-2 disease have higher antibody titers against viral proteins and neutralization capabilities compared to less severe cases.

This study identifies two monoclonal antibodies that bind SARS-CoV-2 spike protein RBM and inhibit GM-CSF induction in immune cells.

This study integrates multi-omic data to construct a regulatory network of brassinosteroid response in Arabidopsis, identifying key phosphorylation sites and a novel transcription factor involved in cell division.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

This study shows that ACE2 is a target of the γ-secretase complex, leading to the release of a soluble C-terminal fragment and altered trafficking of ACE2.

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

The paper models conformational changes in the full-length insulin receptor during activation, identifying two possible transition pathways and analyzing domain motions.

This study compares SARS-CoV-2 strains in hamsters, finding that the D614G spike variant shows higher replication and transmission efficiency.

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

The paper observes mitochondrial biogenesis as an early event preceding radiation-induced apoptosis in living cells using a dual fluorescence reporter system.

This study develops a machine learning model to predict genetic redundancy in Arabidopsis thaliana using diverse features, identifying key predictors like recent duplication and stress-related expression.

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

This paper develops a mouse model of prostatic inflammation and collagen accumulation using E. coli UTI89 instillations to study aberrant collagen production in the prostate.

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

This study screens a botanical drug library to identify inhibitors of Lassa virus entry, finding two compounds with distinct mechanisms of action.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

This study predicts plant metabolic pathway memberships using gene expression data and machine learning, finding that unsupervised learning and expression similarity outperform naive methods in some cases.

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This study shows that MSR1 promotes VSV infection in the spinal cord by acting as a receptor, and its absence reduces viral load and mortality in mice.

This study identifies novel transcription terminators in maize that enhance transgene expression by overlapping poly(A) signals, with specific motifs like AUGAAU showing functional significance.