Q. Sun

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

This study shows that genome doubling in allopolyploids can recover transcriptional and splicing changes from hybridization, partially fixing heterosis and revealing new insights into transcriptome reprogramming mechanisms.

This study analyzes gut microbiome data from 361 elderly women to explore its association with bone mass loss and bone mineral density.

This paper develops a molecular clamping assay called ColoScape for early colorectal cancer detection using XNA-mediated qPCR, showing high sensitivity and specificity in clinical samples.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

The paper determines the crystal structure of the INTS3/INTS6 complex and shows that INTS3 dimerization is crucial for DSB repair.

This study shows that Scutellaria baicalensis extract and its compound baicalein inhibit SARS-CoV-2 replication and 3CLpro activity in vitro.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

The paper uses protein-proofed single-cell RNA profiling to identify tissue cells vulnerable to SARS-CoV-2 infection across 36 tissues, revealing lung and cardiac cells as top targets.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This study shows that introducing cellulolytic bacteria into C. elegans allows the host to utilize cellulose as a carbon source, improving nutrition and larval yield.

This study identifies a policing behavior in termites that regulates reproductive division of labor by older reproductives attacking younger ones, with worker assistance in cannibalizing the injured.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

This study classifies RNase H-like domain-containing proteins in plants, identifying 27 clusters and highlighting their potential roles in DNA replication, RNA transcription, and nucleic acid degradation.

This study identifies two distinct mechanisms regulating PARP2 levels in vitro: ubiquitin-proteasome degradation with serum and sequestration into an insoluble fraction without serum.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

The paper identifies intronic heterochromatin as a mechanism suppressing cryptic transcription initiation by TEs in Arabidopsis.

This study compares lane keeping and speed control between post-stroke and normal older drivers using vehicle tracking data, finding higher lane deviation in complex tasks for post-stroke drivers but no speed differences.

This study shows that LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 by regulating cholesterol homeostasis and immune response genes.

This study shows chronic stress increases oxytocin levels, which promotes melanoma metastasis via β-arrestin 2-dependent pathways, suggesting OXT as a therapeutic target.

This study shows that osteoclast precursor cells migrate toward low fluid shear stress regions, regulated by calcium signaling, under gradient fluid shear stress.

The paper analyzes miRNA expression in serum exosomes from healthy controls, latent TB, and active TB to identify differentially expressed miRNAs and their potential roles in TB progression.

This study compares the nuclear export and cargo dissociation mechanisms of RanBP1 in fungi and animals, revealing distinct interactions and complex stoichiometry.

This study shows that neotenic reproductives in termites regulate worker-reproductive transition differently in males and females, inhibiting same-sex workers and stimulating opposite-sex workers.