Q. Wang

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

The paper quantifies apoptosis and clonal deletion during B lymphocyte development, finding that most peripheral B cell death results from failed selection rather than clonal deletion.

This study predicts post-mining land use in the Hongliulin mining area using random forest and DBSCAN, achieving 95% classification accuracy with 1 miss-classified sample.

The paper identifies STC2 as a biomarker for hepatocellular carcinoma, showing its expression is increased in Nrf1α-deficient cells and decreased in Nrf2-deficient cells, with STC2 promoting tumor growth.

This study theoretically analyzes the dynamics of single-base editing, showing that target and bystander products can be temporarily separated, suggesting dynamic selectivity improves precision.

This study shows that the ancestral spike in bivalent COVID-19 vaccines causes deep immunological imprinting, limiting antibody breadth against Omicron subvariants.

The paper identifies an antibody with broad neutralization against SARS-CoV-2 Omicron variants and shows how somatic mutations enhance its neutralization breadth and potency.

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

This paper introduces MINT, a decoder for brain-computer interfaces that uses statistical constraints, outperforming interpretable methods and competing with machine learning approaches in multiple tasks.

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

This study shows HCC-1 promotes atherosclerosis by inducing pyroptosis in endothelial cells and macrophages and suggests it as an early diagnostic biomarker.

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

This study identifies the CARD8 inflammasome as a driver of CD4+ T-cell depletion in HIV-1 infection through non-productive viral sensing.

This study develops a high-throughput assay to quantify SARS-CoV-2 spike-mediated cell-cell fusion and finds that it is more resistant to antibody inhibition than cell-free infection.

The study functionally characterizes ACPAs from RA patients and shows they reduce arthritis severity in a mouse model, with effects dependent on timing of treatment.

The paper identifies clomiphene, a selective estrogen receptor modulator, as an inhibitor of plant sterol biosynthesis by targeting CPI1, suggesting its potential for agricultural applications.

This study investigates allosteric communication in the ClpP peptidase gating mechanism by analyzing conformational changes and network rewiring during pore opening.

This study identifies three R2R3-MYB transcription factors that regulate spot-specific malonylated anthocyanin production in Gorteria diffusa petals.

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

This paper predicts outcomes of BPaMZ tuberculosis treatment regimens using a translational preclinical mouse to human platform, showing potential to shorten treatment duration and prevent relapse.

This study compares neutralizing antibody titers after bivalent and monovalent mRNA boosters and BA.5 breakthrough infection, finding no significant difference at one month but higher titers in breakthrough patients at three months.

The paper identifies a distinct photoperiodic growth regulation pathway in plants that operates independently from the flowering pathway, using different mechanisms to detect photoperiod.

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

The paper shows that V0d inhibits V0c interactions with complexin and SNAREs, reducing neurotransmission in neurons.

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

This study shows that loss of WNT5A and WNT5B in mice protects against DSS-induced colitis by reprogramming spleen neutrophils to suppress inflammation.

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

The paper predicts clinical efficacy of antituberculosis drugs using preclinical PKPD data and translational pharmacology models to reduce phase 2a trial costs and failures.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.