Q. Wang

This paper characterizes HIV-1 Env conformational states on virions and shows how stabilizing the pretriggered State-1 conformation enhances bNAb recognition and reduces shedding.

This study identifies oxidized thioredoxin-1 as a repressor of NLRP1 inflammasome activation, showing that mutations impair this interaction and cause autoinflammatory disease.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

OPUS-DSD improves cryo-EM reconstruction by resolving structural heterogeneity and enhancing homogeneity in datasets, outperforming existing methods on synthetic and real data.

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.

This study shows lysosomes mediate the mitochondrial UPR through mTORC1-dependent ATF4 phosphorylation, essential for mitochondrial redox homeostasis and cell survival under stress.

The paper demonstrates the existence of protein complexes in the dilute phase of phase-separating systems using an algal pyrenoid reconstitution system and fluorescence correlation spectroscopy.

This study identifies a cis element that represses the glp operon in Borrelia burgdorferi, independent of RpoS, and shows BadR binds to this element, with binding efficiency influenced by c-di-GMP and carbohydrates.

This paper uses integrated PET and confocal imaging to establish a spatiotemporal timeline for vascular reconnection during grafting in tomato.

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

This study identifies P2RY2 as a key purinergic receptor involved in pancreatic cancer invasion through interactions with integrins, suggesting therapeutic targeting potential.

This study compares neutralizing antibody responses to bivalent and monovalent mRNA vaccines against SARS-CoV-2 variants, finding similar titers for bivalent vaccines against Omicron BA.4/BA.5 and ancestral strains.

The paper shows GLVs induce similar early stress responses as DAMPs by altering phosphorylation of proteins involved in signaling pathways.

This paper develops and tests a CD46-targeted alpha radioimmunotherapy, 212Pb-TCMC-YS5, showing potent tumor growth inhibition and survival improvement in multiple prostate cancer models.

This study demonstrates a 4-fold photoacoustic amplification in silica-coated gold nanoparticles using picosecond laser excitation, attributed to interface heat transfer mechanisms.

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

This study evaluates the neutralization resistance of SARS-CoV-2 Omicron subvariants BA.4.6, BA.4.7, and BA.5.9 to antibodies, finding increased resistance to certain monoclonal antibodies and vaccine-induced sera.

This paper introduces a microfluidic dielectrophoresis method to rapidly distinguish E. coli with different LPS structures by analyzing electrokinetic properties.

This study identifies DCX and JIP3 as neural-specific regulators that counteract each other in dynein-mediated retrograde trafficking by modulating dynein-microtubule binding and motor complex composition.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.

This paper identifies a lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan in worms and mammalian cells by enhancing protein aggregate clearance.

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

This study develops Nm-VAQ, a qPCR-based method to precisely validate and quantify RNA 2'-O-methylation sites, demonstrating its application on rRNA.

This paper develops an ultra-small bispecific fusion protein, Bi-fp50, that improves tumor penetration and treatment efficacy for pancreatic cancer by targeting EGFR and VEGF.

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

This study shows that PKD promotes prostate cancer bone metastasis by regulating Runx2 via MEK/ERK1/2 signaling, and inhibiting PKD reduces metastasis in mice.

The paper identifies a nonsynonymous SNP in MePOLD1 as the causal mutation for CMD2-type resistance to Cassava Mosaic Geminiviruses, validated through virus-induced gene silencing and allele analysis.