Author

S. Chiu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Organism:rat· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Y. Wu· 5 shared H. Zhang· 4 shared S. Chen· 4 shared J. Zhou· 3 shared T. Jin· 3 shared Y. Yang· 3 shared C. Yang· 2 shared D. Chen· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

Y. Wu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

Y.-W. Luo, J.-P. Zhou, H. Ji, A. Zheng, X. Wang, Z. Dai, Z. Luo, F. Cao, X.-Y. Wang, Y. Bai, D. Chen, Y. Chen, Q. Wang, Y. Yang, X. Zhang, , K.-F. Tang

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

K. Sun, Z. Ding, X. Jia, H. Cheng, Y. Li, Y. Wu, Z. Li, X. Huang, F. Pu, E. Li, G. Wang, W. Wang, Y. Ding, G. Wong, S. Chiu, , A. Hu

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

bioRxiv · Nov 24, 2022Biochemistry

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

Y. Wu, Y. Shen, N. Wu, X. Zhang, S. Chen, C. Yang, J. Zhou, Y. Wu, D. Chen, L. Wang, Y. Wang, J. Xu, K. Liu, C. Wang, H. Zhang, , Y. Wang

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

Cell Research · Aug 1, 2022Peer-reviewedMicrobiology

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

X. Zhang, F. Luo, H. Zhang, H. Guo, J. Zhou, T. Li, S. Chen, S. Song, M. Shen, Y. Wu, Y. Gao, X. Han, Y. Wang, C. Hu, Y. Lu, , A. Huang

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

bioRxiv · Apr 26, 2022 · PreprintImmunology

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

T. Jin, H. Ma, X. Zhang, P. Zheng, P. H. Dube, W. Zeng, S. Chen, Y. Yang, Y. Wu, J. Zhou, X. Hu, Y. Xiang, H. Zhang, S. Chiu

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

bioRxiv · Mar 8, 2022Immunology

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

D. Tong, M. Zhang, Y. Yang, H. Xia, H. Tong, H. Zhang, W. Zeng, M. Liu, Y. Wu, H. Ma, X. Hu, W. Liu, Y. Cai, Y. Yao, Y. Yao, , T. Xue

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

bioRxiv · May 19, 2021Immunology