S. Han

This study shows that recently evolved genes in Drosophila compensate for meiotic X chromosomal inactivation by rapidly adapting in post-transcriptional and translational regulation.

This study uses smFRET to examine real-time conformational dynamics of the hHv1 voltage sensor under different voltage and pH conditions, revealing that gating is determined by conformational distributions rather than transitions between resting and activated states.

This study shows persistent DNA damage alters lipid metabolism and histone acetylation via MYS-1/Tip60, leading to immune-like responses and age-related decline.

HuConTest detects human contamination in short read sequencing data from great apes using blood and tissue samples, showing its utility in complex samples with low endogenous DNA.

The paper develops a metabolomics pipeline to identify microbiota-dependent metabolites and explores their links to host phenotypes using machine learning and comparative genomics.

This paper develops an artificial cytosol system using agarose-sucrose to create pH-sensitive liposomes that enhance drug delivery efficiency.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study investigates how Pseudomonas aeruginosa adapts and evolves during coinfection with COVID-19, showing it overexpresses alginate and reduces Type VI secretion system to enhance biofilm formation and suppress virulence.

This study shows financial incentives enhance prosocial motivation in low empathic individuals by increasing anterior insula activation, with less effect on high empathic individuals.

This study shows that esophageal epithelial cells can convert to hair follicle identity when exposed to skin stroma, with HIF1a inhibition blocking this transition.

The paper investigates how mechanical changes in the mouse esophagus regulate the transition to homeostasis by identifying a committed progenitor population through single-cell RNA sequencing and organ stretching experiments.

This study investigates how beliefs about others' pain influence empathy and altruism through neural mechanisms, showing reduced empathy and altruism when beliefs of others' pain are decreased.

This study shows that platycodin D inhibits SARS-CoV-2 infection by blocking lysosome- and TMPRSS2-driven entry through membrane cholesterol redistribution.

This study identifies the intrinsically disordered C-terminus of the human A2A receptor as the driver of its homo-oligomerization through multiple interaction types.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.

The paper identifies proximal tubule cell state and metabolism as coupled by nuclear receptors in kidney disease using single-cell RNA-sequencing.

This paper reports on a prefusion SARS-CoV-2 spike RNA vaccine that induces strong immune responses and prevents lung infection in non-human primates.

This study identifies AATRhg1 as an amino acid transporter that increases in abundance during soybean cyst nematode penetration and interacts with GmRBOHC2 to enhance ROS production, contributing to resistance.

This paper develops membrane nanoparticles from ACE2-rich cells that effectively block SARS-CoV-2 infection by trapping the viral S1 protein and inhibiting its interaction with host cells.

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

The paper describes a genetically adapted Pseudomonas aeruginosa small colony variant causing persistent bacterial coinfection in a COVID-19 patient, showing enhanced biofilm formation and quorum sensing.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

This study shows that background speech and white noise improve visual working memory by increasing arousal, as measured by physiological signals.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This study uses optical diffraction tomography to observe 3D changes in individual bacteria under antibiotic treatment, quantifying their responses to ampicillin.

This study shows that S. thermophilus 19 reduces inflammation in septic mice by remodeling gut microbiota.

This study investigates how hepatitis C virus (HCV) infection affects choline metabolism in liver cells, showing that choline transport and metabolism are modulated during early infection, with varying effects depending on culture conditions.

This paper introduces a rapid antimicrobial susceptibility test using laser speckle dynamics to detect bacterial growth in 2-4.5 hours.