T. Li

The paper develops a domain-specific CRISPR-Cas9 system with live-imaging screening in Arabidopsis to study PIN1 function in tissue morphogenesis and mechanical stress response at single-cell resolution.

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

The paper identifies co-occurring RAS-MAPK pathway alterations in MET exon 14 skipping mutation positive lung cancers that limit response to MET inhibitors and suggests combining MET and MEK inhibitors to overcome resistance.

The paper develops improved CRISPR/Cas9 methods for genome editing in Culex quinquefasciatus, achieving higher embryo survival and germline mutagenesis rates.

This study presents a neural network model of the hippocampal-entorhinal loop to investigate how visual and self-motion cues influence spatial representation in multi-compartment environments.

The paper uses shotgun metagenomics to analyze the gut microbiome in AS patients, finding enriched bacterial epitopes linked to HLA-B27 and effects of TNFi therapy and host genotype on microbiome composition.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

This study uses single-cell RNA sequencing and metabolic profiling to identify metabolic signatures of durable T cell memory in DENV vaccine responses.

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

This study identifies BmNPC1 as a critical host receptor for baculovirus infection, showing its interaction with the viral glycoprotein gp64 and role in endosomal fusion.

The paper shows that elevated O-GlcNAcylation in CD4+ T cells enhances Th17 function by altering the lipid microenvironment, increasing IL-17A production in obesity.

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.

This study infects pregnant marmosets with Zika virus, leading to fetal loss and neurodevelopmental issues, mirroring human congenital ZIKV disease.

This study infects marmosets with Zika virus and finds they exhibit key features of human disease, including asymptomatic infection and viral persistence in lymph nodes.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

This study identifies and characterizes NF-Y transcription factors involved in rice endosperm development, showing sub-functionalization and interaction patterns among subunits.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.

This study tracks the molecular evolution of a pediatric ependymoma through multiple treatments, revealing how therapy shapes tumor subclonal diversity and neo-antigen landscapes.

The paper evaluates the PURE system for in vitro protein synthesis, identifying factors affecting protein yield and activity, and proposes optimizations to improve performance.