X. Cheng

The paper identifies HemK2/KMT9 as a new target of NTMT1 bisubstrate inhibitor NAH-C3-GPKK through chemoproteomic profiling.

The paper compares observed parasitism rates from field mummy counts with actual parasitism rates from laboratory-reared parasitoids in canola crops, finding actual rates are significantly higher than observed.

This paper introduces a bifocal parallax single particle tracking method to study 3D rotational and translational motion of cargo in living cells, revealing new interactions at microtubule intersections.

This study reports the crystal structure of gp16-CTD and simulations of the full-length gp16, revealing its role in dsDNA packaging through interactions with pRNA and dynamic domain interplay, refining the inchworm-revolution model.

The paper identifies amyloid-forming segments in SARS-CoV-2 Nucleoprotein and designs peptide inhibitors based on their atomic structures to target Covid-19.

This study compares bacterial diversity in chronic middle ear lesions using 16S rRNA gene sequencing, finding greater diversity in cholesteatoma than in chronic suppurative otitis media lesions.

This study examines how parasitaemia levels during Plasmodium yoelii infection in mice affect intestinal microbiota composition and correlate with immune cell development.

This study identifies SABRE's role in ER dynamics and callose deposition during cell plate maturation, revealing its essential function in cell and tissue patterning across eukaryotes.

The paper develops a brachial artery relaxation index (BARI) to predict abdominal aortic aneurysm (AAA) growth but finds no significant correlation between BARI and future AAA growth.

This study uses WEBD simulations to analyze vWF multimer unfolding in extensional flow, showing that pathological unfolding is unlikely below 2000 s-1 strain rate.

This study shows that JNK1/2 phosphorylates BNIP3 under hypoxia, enhancing its stability and promoting mitophagy by increasing its binding to LC3.

This study identifies potential inhibitors of the SARS-CoV2 Nsp13 helicase through virtual screening and experimental validation of approved drugs.

This study uses a zebrafish model of granulin deficiency to show granulin's role in myeloid cell differentiation and wound healing.

This study shows that reconstituting the gut microbiota in germ-free rats accelerates bone growth and alters marrow cell composition, with effects linked to increased short-chain fatty acids and IGF-1 levels.

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

VolcanoFinder detects adaptive introgression using polymorphism data from a single population, identifying volcano-shaped patterns of increased variability around beneficial alleles.

The paper quantifies intrinsic strengths of atom-atom interactions in amides relative to water, providing insights into their roles in protein self-assembly and stability.

This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

This study identifies METTL5 as an 18S rRNA-specific m6A methyltransferase that modulates stress response gene expression by affecting translation.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

This study investigates the structure-activity relationship of cinnamodial analogues against Aedes aegypti, identifying key functional groups for larvicidal, adulticidal, and antifeedant activity.

This paper introduces B statistics, a set of mixture model-based tests for detecting balancing selection, showing robust performance across window sizes and datasets.

This study introduces a new teaching method for medical statistics called PDTR, which improves student performance and reduces class hours compared to traditional methods.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

The paper develops methods to detect trans-species balancing selection without relying on trans-species polymorphism, finding new genomic regions linked to immunity and barrier integrity in humans and chimpanzees.

This study uses simulations to show that A2 domain unfolding in vWF multimers under shear flow occurs preferentially near the center of unraveled multimers, with threshold shear rates inversely related to multimer length.

This study shows EPAC1 interacts with AnxA2, modulates its membrane translocation, and inhibits plasminogen activation in endothelial cells, suggesting a role in fibrinolysis regulation.