Y. Liu

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

The paper demonstrates DNA-controlled microgel automata that transform between complex shapes using designed DNA sequences and neural networks.

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

This study identifies the metabolic niche of Eggerthella lenta in the human gut by combining experimental and computational approaches, revealing its use of acetate and arginine catabolism.

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

This paper presents a biomaterial platform that enhances adoptive T cell therapy by engaging the host immune system, leading to better tumor control and long-term protection against solid tumors.

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.

This study shows that apelin-13 enhances muscle regeneration in dystrophic mice by stimulating endothelial cells in the perivascular niche, improving MuSC function and tissue repair.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

The paper develops a microfluidic immuno-serology assay to analyze immune responses in patients with altered immunity, finding reduced diversity in protein cooperation and impaired antibody responses in certain groups.

This study identifies RGMB-AS1 as an upregulated lncRNA in PAH that modulates BMPR2 signaling and improves vascular cell function when inhibited.

This study uses urinary proteomics in ApoE-/- mice to identify early biomarkers of atherosclerosis by comparing high-fat diet-induced changes with control groups.

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

The paper determines the structures and functions of minor pilins in Streptococcus sanguinis T4P, showing they form a tip complex that mediates adhesion to host glycans.

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

The paper identifies two bacterial genes enabling acesulfame degradation, showing their recent evolution and global spread through plasmid transposition.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

The paper investigates the immunomodulatory effect of D-MAPS and finds a balance between pro-inflammatory and pro-reparative macrophages in regenerative scaffolds.

The paper introduces a tool to estimate microbe abundances in tumor RNAseq data and identifies associations between microbes and clinical outcomes.

This study investigates how spatial confinement in microporous scaffolds affects macrophage polarization and inflammatory response.

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.

This study shows that pre-activating γδT cells with IL-12/18/21 enhances their anti-tumor activity and overcomes resistance to anti-PD-L1 therapy in mouse models.

The paper shows that the tumor extracellular matrix educates macrophages to adopt a phenotype seen in ovarian cancer metastasis, affecting T cell function and immune regulation.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

This study shows that β1-containing integrins are essential for alveolar repair after injury, as their absence leads to emphysema and impaired differentiation of AT2 cells into mature type 1 alveolar epithelial cells.

This paper introduces CP-seq, a method to test thousands of drug combinations on single cells using microwell-based droplet random pairing and single-cell RNA sequencing.

This study shows that SARS-CoV-2 ORF8 protein acts as a cytokine that promotes lung inflammation and immune dysregulation in COVID-19, suggesting it as a potential therapeutic target.