Y. Lu

This paper introduces TRAP, a method for detecting exosomal miRNAs with high sensitivity and selectivity, showing improved detection limits compared to qRT-PCR.

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

This paper characterizes superferromagnetic remanence in nanoparticles and optimizes MPI scanning for improved resolution and signal.

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

This study investigates the evolutionary conservation of m6A-related genes in insects and identifies METTL3's role in silkworm embryonic development through functional analysis.

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

The paper investigates freeze tolerance in the Amur sleeper using genomic, transcriptomic, and metabolomic analyses to identify genetic and molecular mechanisms underlying this adaptation.

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

The paper introduces the Swarm, a high-throughput optogenetic platform for screening ion channel modulators in excitable cells, demonstrating its utility in drug discovery for nervous system disorders and cardiac toxicity.

This study shows that Mmp14 regulates circadian rhythms and matrisome homeostasis in tendon fibroblasts by controlling collagen fibril synthesis and crosslinking.

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

The paper determines the complete sequences of velvet worm slime proteins and identifies disulfide bonds and intrinsically disordered regions as key to slime self-assembly.

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

This paper develops a non-invasive drug administration method for adult zebrafish using food-based drug pellets, enabling long-term treatment studies and modeling drug resistance in melanoma.

The paper shows that DNA-scaffolded bacteriophage repressor complexes do not effectively block transcription by E. coli RNA polymerase.

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

This study investigates whether lipid extracts from various mycobacterial strains inhibit the NPC1 pathway, finding that inhibition occurs in most strains but not in Mycobacterium canettii.

The paper generates a single-cell atlas of Arabidopsis root phloem pole cells and identifies PINEAPPLE genes as key regulators in the transition to autotrophy.

The paper identifies Mfn2 as a preferred Parkin substrate due to its proximity to PINK1, which facilitates Parkin activation and ubiquitination on mitochondria.

This study identifies CatSper{tau}, a C2cd6-encoded protein, as a critical targeting component for the CatSper Ca2+ channel to the flagellar Ca2+ signaling nanodomains, essential for sperm motility and fertility.

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

The paper develops a free-energy landscape model of the proteasome ATPase complex to reveal how ATP hydrolysis drives substrate translocation through cooperative subunit movements.