B. Zhao

The paper investigates the structural basis of latency in TGF-beta family members by comparing conformational states and hydrogen-deuterium exchange patterns across multiple family members.

This paper develops RNA-based fluorescent sensors to directly image and measure (p)ppGpp in live bacterial cells, revealing cell-to-cell variation and dynamics under different nutritional conditions.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study investigates the role of CTPS1 and CTPS2 in EBV-infected B-cells, showing their importance in cell growth and survival, and suggests they are potential therapeutic targets.

Ilomastat improves mouse survival after irradiation by enhancing hematopoietic recovery through reduced inflammation and increased stem cell counts.

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.

This study identifies key amino acid residues in the vaccinia VH1 phosphatase that mediate substrate recognition and dephosphorylation, offering new targets for inhibitor development.

This study compares antioxidant enzyme activity, dehydrin expression, and gene expression in two switchgrass cultivars under drought stress to identify markers of drought tolerance.

This study identifies CAF1 and HIRA as host histone chaperones essential for maintaining Epstein-Barr virus latency by restricting lytic reactivation in Burkitt cells.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.

This study shows that SIRT1 and SIRT6 work together to recognize DNA breaks and enhance the DNA damage response and repair.

This study uses iTRAQ proteomics to analyze the HCC secretome, identifying CA2 as a diagnostic and prognostic biomarker with potential therapeutic implications.

This paper introduces a DNA-based fluorescent probe, DNAMeter, to quantify intercellular tensile forces through real-time imaging and fluorescence signal activation.

The paper identifies a pH-dependent structural dynamic in pre-miR-21 that enhances Dicer processing through a protonated A+-G mismatch.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This paper identifies a new principle in drug resistance where the most likely mutations, not the most resistant ones, dominate clinical outcomes, suggesting a strategy to minimize resistance through drug design.

This paper extends the BAC TG-EMBED method to enable versatile, stable, and reproducible multi-transgene expression in mammalian cells using episomal and integrated BAC constructs.

The paper develops a method to image sub-organellar actin dynamics using fluorescent actin nanobodies and finds ER-associated actin drives organelle fission.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

The paper introduces PAFit, a method to measure ecological topic popularity in a temporal network, showing it outperforms frequency-based approaches.

This paper develops a deep transfer learning method to classify LDIH holograms without image reconstruction, enabling low-cost point-of-care diagnostics.

This study shows Tolloid cleavage activates latent GDF8 by destabilizing prodomain-growth factor interfaces and priming the growth factor for release.

The paper determines the structure of pro-TGF-β1 with a cleavage site mutation, revealing prodomain-GF domain swapping in the dimeric structure and its implications for TGF-β biosynthesis.

This study shows FGF21 reduces melanogenesis in alpaca melanocytes by activating ERK1/2 and downregulating MITF, leading to decreased melanin production.