C. Liu

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper shows that phase separation of SEC14-like protein, mediated by proteolysis, maintains auxin efflux carrier polarity at Arabidopsis plasma membranes, contributing to root developmental robustness.

The paper introduces a microfluidic chip for co-culture studies that enables controlled paracrine signaling and high throughput.

The paper shows that CMT3 and KRYPTONITE maintain the sulfurea paramutation in tomato by affecting CHG hypermethylation and chromatin structure, but not the PolV-dependent RdDM pathway.

The paper compares fluid viscosity, pH, and calcium concentration in the reproductive tracts of polyandrous and monogamous Peromyscus mice to assess post-copulatory sexual selection effects.

This paper introduces a beaded-ring pattern for two-photon optogenetics to improve axial resolution in vivo, showing a 24% improvement over disk patterns when stimulating multiple neurons.

This study tests how varying treadmill terrain unevenness affects gait kinematic variability and perceived stability in younger and older adults.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study shows TP53 knockout in breast cancer cells increases sensitivity to fluoropyrimidine drugs like F10, with DNA incorporation as a key mechanism.

This study identifies a highly attenuated SARS-CoV-2 related pangolin coronavirus variant with a 104nt deletion in the 3'-UTR HVR, showing reduced virulence in vitro and in vivo.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

This study shows EFEMP1 is crucial for elastic fiber formation and mechanical properties of the extrahepatic bile duct, with reduced EFEMP1 leading to increased compliance and potential role in biliary atresia.

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

The paper examines stomatal trait variation across forests, finding that stomatal conductance (g) and area fraction (f) show different patterns of variance and skewness, with implications for ecosystem productivity.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

This study develops a non-integrating episomal reprogramming method to generate iPSCs from PBMCs with high cytogenetic stability and minimal genomic aberrations.

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.

This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.

The paper investigates mechanical forces during oogenesis in C. elegans and finds that a lamin meshwork counteracts LINC-mediated forces to prevent nuclear collapse.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This paper introduces a method to monitor phloem and xylem reconnections in grafted watermelon seedlings using specific fluorescent tracers and finds that vascular reconnections are not timely separated in self-grafted watermelon.