H. Yan

This study experimentally examines how toehold length, location, and mismatches affect strand displacement kinetics in RNA and RNA-DNA hybrid systems.

This study identifies FlbA1 and FlbA2 as regulators of fumonisin B1 biosynthesis in Fusarium verticillioides, showing FlbA2 inhibits FB1 production while FlbA1 has no significant effect.

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study investigates the functions of Mediator subunits in Fusarium verticillioides, showing that some subunits have unique regulatory roles in development, stress response, and secondary metabolism.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This paper introduces PlantU-net, an end-to-end segmentation network for maize seedling phenotyping from top-view images, achieving high accuracy with minimal training data.

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

This study uses HDX-MS to analyze glycan-induced structural dynamics in norovirus P dimers across strains and deamidation states, revealing strain- and deamidation-dependent changes in protein flexibility and solvent exposure.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

The paper shows that many bat species cannot host SARS-CoV or SARS-CoV-2 due to ACE2 receptor incompatibility, with genetic analysis identifying restrictions to viral entry.

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

The paper investigates nevus growth arrest using a mouse model and finds that collective cell behavior, not cell-autonomous senescence, explains nevus size control.

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

This study investigates how loop extrusion factors and chromatin structure influence chromatin dynamics using microscopy, genetics, and simulations in fission yeast.

This study investigates the immune response of macrophages to mucin hydrogels, showing sialic acid-dependent activation of cytokines and markers, with effects diminishing by day 7.

This study identifies and characterizes FvGbb2, a putative G{beta}-like protein in Fusarium verticillioides, showing its role in fumonisin biosynthesis, growth, and stress response.

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.

This study shows that FvSec4 is essential for hyphal development, virulence, fumonisin B1 production, and stress response in Fusarium verticillioides.

This study develops mucin hydrogels that reduce fibrotic encapsulation in vivo by modulating immune responses, showing reduced fibrosis and immune cell recruitment compared to alginate hydrogels.

The paper investigates phylogenetic relationships among Avena taxa using the Pgk1 gene, revealing structural divergence and evolutionary relationships between genomes.

This study shows HBV inhibits neutrophil extracellular traps (NETs) release by reducing reactive oxygen species (ROS) and autophagy, contributing to chronic infection.

The paper shows MTAP loss in GBM correlates with an immunosuppressive profile by increasing M2 macrophages and that MTA, a byproduct of MTAP loss, promotes this effect through the A2B receptor.

The paper develops a platform to infer and validate signaling interactions at cellular resolution during C. elegans embryogenesis, identifying Notch interactions and their role in breaking fate symmetry.

The paper identifies virulence-related subnetwork modules in Fusarium verticillioides using co-expression analysis and predicts maize genes responding to fungal virulence factors.