J. Wu

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

This study identifies Zbtb46 as a regulator that coordinates angiogenesis and immunity in tumors, with its downregulation promoting a pro-tumor microenvironment and its restoration improving tumor outcomes.

This study shows that balanced nitrogen-iron nutrition increases tiller number, yield, and nitrogen use efficiency in rice and wheat through the NIN-like protein 4 mechanism.

This study identifies the OsNLP3/4-OsRFL module as a key regulator of nitrogen-promoted panicle architecture in rice, linking nutrient availability to developmental outcomes.

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study shows that GDF15 promotes osteoclast fusion and angiogenesis in endplate instability, and inhibiting GDF15 alleviates low back pain.

This study investigates how giant viruses adapt to polar ocean environments by analyzing their biogeography and functional genes, finding that their adaptation is independent of host adaptation.

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

The paper identifies NaWRKY70 as a key regulator integrating jasmonate and ethylene signals to synergistically induce phytoalexin biosynthesis in response to Alternaria alternata.

This paper uses single-molecule nanopore dielectrophoresis to study α-Synuclein folding and unfolding in lipid membranes and how metal ions and peptidomimetics affect these processes.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

This paper establishes a human iPSC-based in vitro assay to assess neurodevelopmental toxicity of pesticides by evaluating neural network formation and function.

This paper introduces MUSI, a rapid, label-free imaging method for lung adenocarcinomas, showing it can differentiate subtypes with resolution comparable to FFPE histology.

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

This paper introduces DeepSeMi, a self-supervised denoising framework that enhances fluorescence microscopy by increasing SNR and enabling long-term, high-resolution imaging of cellular processes.

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

This study uses simulations and HDX-MS to analyze how two LRRK2 inhibitors affect the protein's conformational dynamics and kinase activity.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study examines how elephants adjust their trunk grip strategies for different weights and finds that heavier weights are associated with increased wrapping surface area and constant tensile force.

The paper identifies PELO as a catalyzer required for the ATPase activation and sequential assembly of NLR family proteins into functional complexes.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

This study shows that planting diverse tree mixtures in logged forests accelerates restoration rates in a large field experiment.

This study shows that UHRF1 upregulation drives exosome release and tumor progression in osteosarcoma by promoting metastasis and cell mobility.

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

The paper develops a single-cell multi-omics platform to simultaneously profile transcriptome and proteome in mouse oocytes, revealing transcriptome-proteome heterogeneity and identifying maturational signatures.