J. Wu

This study develops a stapled peptide inhibitor that blocks talin-induced integrin activation by targeting both talin head and rod domains.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

This study identifies the OsNLP4-OsMADS27 module as a nitrate-dependent regulator of salt tolerance in rice, showing its role in stress response and yield improvement under salt stress.

This study identifies IL-1 and LIF as factors promoting EMH by activating splenic niche cells and inducing an inflammatory gene signature in HSPCs.

This study reports cryo-EM structures of modified IGF1R and IR complexes, showing that disulfide-linked CTs are critical for receptor activation and signaling.

The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.

The paper develops PiSPA, a single-cell proteomic workflow, to quantify up to 3000 protein groups in tumor cells, demonstrating its utility in studying single-cell proteome dynamics.

Fossil-explorer.com is an interactive tool for exploring fossil data that addresses visual clutter and limited interaction, efficiently handling millions of data points.

This study ablates SYK kinase in primary human NK cells using CRISPR/Cas9, finding it enhances cytotoxicity and cytokine production compared to other gene ablations.

This study shows NEMP1 is essential for nuclear envelope openings and enucleation in erythroblasts, leading to anemia and splenomegaly in Nemp1 knockout mice.

This study shows that neutrophil-tropic nanoparticles enhance phagocytosis of non-opsonized bacteria by ~50%, suggesting their potential as drug carriers for bacterial infections.

This study compares genomes of orobanchaceous plants with different parasitic lifestyles to trace the evolutionary steps of plant parasitism.

This study identifies early urinary biomarkers in a rat model of multiple sclerosis and shows that early treatment with methylprednisolone reduces disease incidence.

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

This study examines how soluble proteins and kernel hardness affect starch digestibility in wheat flour, finding that soluble proteins significantly reduce digestion even after gastric proteolysis.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.