P. Wang

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

This study shows filamentous recombinant human Tau activates astrocytes via integrin V/{beta}1 receptor, leading to neurotoxic effects through NF{kappa}B signaling.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study shows pen-strep increases macrophage stiffness and promotes cell spreading on various ECM substrates through YAP-1/TAZ upregulation and β1 integrin downregulation.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

The paper studies the evolution of a gene cluster in Solanaceae plants and its role in producing medium chain acylsugars through trichome-specific enzymes.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This study identifies differential host gene signatures in response to various Mycobacterium tuberculosis strains, highlighting distinct immune responses associated with isoniazid resistance.

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

The paper introduces a deep learning method to predict virus hosts using DNA sequences, applied to 2019-nCoV to identify potential hosts like bats and minks.

The paper uses transfer learning to predict specialized metabolism genes in tomato by leveraging annotations from Arabidopsis thaliana, improving prediction accuracy.

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

This study identifies Lyn-dependent secretory autophagosomes as a novel pathway for flavivirus secretion, enabling evasion of antibodies and tissue tropism.

This study shows IL-12 enhances B16F0 melanoma cell survival through non-canonical PI3K-AKT signaling, distinct from its canonical role in immune cells.

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

This study compares bacterial diversity in raw and pasteurized goat milk using high-throughput sequencing, identifying new bacterial species and viable but nonculturable bacteria.

This study shows that bacterial flagella are not permanent structures, dynamically produced and lost during growth phases, with glucose availability influencing their disassembly.