S. Feng

This study shows MAGI2-AS3 suppresses acute lymphoblastic leukemia growth by regulating the miR-452-5p/FOXN3 axis, affecting proliferation, apoptosis, and glycolysis.

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

The paper develops a method to release lipids from the vacuole in yeast to study lipid metabolism and transport, showing Mdm1 facilitates sphingoid base to ceramide conversion and cholesterol can restore cell proliferation under sterol deprivation.

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

This study shows YAP1 promotes breast cancer metastasis by enhancing TIAM1 expression through its enhancer, leading to increased RAC1 activity and invadopodia formation.

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

This study evaluates the efficacy of HCV protease inhibitors against SARS-CoV-2 and their interactions with remdesivir, finding simeprevir shows synergism and is the most promising for future antiviral treatments.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study shows winter wheat adjusts root H+ net flux to adapt to pH stress, with BN4199 showing stronger acid and alkali resistance than AK58.

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

This study evaluates the in vitro antiviral efficacy of Artemisia annua extracts and artemisinin derivatives against SARS-CoV-2, finding artesunate to be the most potent.

This paper adapts SARS-CoV-2 to replicate more efficiently in human cells, enabling antiviral compound screening across multiple cell lines.

The paper improves split fluorescent protein systems for better complementation efficiency and signal amplification in mammalian cells.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study identifies membraneless protein granules formed by RTK oncoproteins that activate RAS/MAPK signaling independently of lipid membranes in cancer.

This study shows that glycyrrhizic acid improves cognitive function in aged mice by enhancing T and B cell proliferation and blood perfusion.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

The paper identifies an interaction between PMD proteins MAIN and MAIL1 with the phosphatase PP7L that regulates gene expression and silences transposable elements in Arabidopsis thaliana.

The paper identifies hypersensitive mutants in lipid biosynthesis and trafficking genes in sphingolipid-depleted cells and shows coordinate regulation of ether and sphingolipids.

This study investigates sex chromosome evolution in paleognath birds, finding that tinamous have higher substitution rates and unique evolutionary strata without chromosomal inversion.

This study identifies β1 integrin as a sensor for blood flow direction in endothelial cells, showing it is activated by unidirectional but not bidirectional shear stress.

This paper investigates how PCV2 binds to heparan sulfate, showing asymmetric binding sites on the capsid and potential inhibition by sulfate-rich polymers.

This paper introduces a computational hyperspectral imaging method that improves reconstruction precision in multicolor fluorescent imaging by using spatial constraints, validated with simulated and experimental data.

This paper introduces a high numerical aperture epi-illumination SPIM system for fast and high-resolution volumetric imaging of live cells and single-molecule super-resolution microscopy.

The paper develops improved split fluorescent proteins for endogenous protein labeling, showing enhanced signal-to-background ratios and new applications in super-resolution microscopy.