S. Li

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

The paper analyzes phorbol ester distribution in Jatropha curcas tissues and links it to gene expression under various stresses.

This study shows neonicotinoids increase methane emission in Periplaneta americana by altering gut bacteria to produce more hydrogen, which methanogens use to generate methane.

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper develops covalently linked graphene oxide affinity grids for cryo-EM, enabling high-resolution reconstructions by preventing particle denaturation and aggregation.

This study evaluates Nanopore sequencing for differentiating Salmonella serotypes and variants with similar antigenic formulas using SNP analysis and prophage prediction.

This study shows that a single dose of spike-functionalized ferritin vaccines in mice generates neutralizing antibodies against SARS-CoV-2, with S{Delta}C-Fer showing higher efficacy than other spike formats.

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

This study shows that eurycomanone promotes lipolysis and reduces fat accumulation by activating the cAMP/PKA pathway in 3T3-L1 cells and C57BL/6J mice.

The paper demonstrates near-atomic resolution structure determination of apoferritin using single-particle cryo-EM with a 300-kV Titan Krios microscope, achieving 1.35 Å resolution and resolving heavy atoms and rotameric configurations.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

The paper uses structural characterization, laser capture microdissection, and transcriptomic sequencing to reveal gene expression patterns regulating early compound leaf morphogenesis in tomato.

The paper presents a 3.4-A cryo-EM structure of the human coronavirus NL63 spike trimer from vitrified virus particles, revealing structural differences from SARS-CoV-2.

The paper identifies QTLs for dynamic and steady state photosynthetic traits in barley, including a QTL for rubisco activation rate on chromosome 7H and overlapping QTLs for steady state traits.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study shows miR-100-5p reduces prostate cancer cell proliferation, migration, and invasion by downregulating mTOR.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This study improves NADPH flux and xylitol production in engineered E. coli by dynamically controlling regulatory metabolites and metabolic pathways.

This study uses dynamic metabolic control to enhance stationary phase biosynthesis in E. coli by targeting citrate synthase and glucose-6-phosphate dehydrogenase, leading to increased acetyl-CoA production and citramalic acid titers.

The paper uses cryo-EM and ASO experiments to study the SARS-CoV-2 FSE structure and its potential as an antiviral target, finding a complex tertiary structure but challenges in effective inactivation.

HiFi-SIM improves structured illumination microscopy image fidelity by reducing artifacts and enhancing axial resolution without requiring precise PSF calibration or parameter tuning.

The paper identifies bystander CD4+ T cells in human tumors, showing they are phenotypically distinct and express CD39, correlating with CD8+ TILs specific for non-cancer antigens.

This meta-analysis evaluates the diagnostic accuracy of RASSF1A promoter methylation in prostate cancer, finding high specificity and area under the ROC curve.

This study investigates how the marine ciliate Mesodinium rubrum controls sequestered cryptophyte organelles, finding limited transcriptional control and significant gene expression from the prey.

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

The paper investigates how cGAS/STING activity is attenuated during mitosis by examining the role of Golgi integrity and mitotic chromosomes.