S. Li

The paper uses computational and experimental methods to control bacterial microcompartment assembly by modifying protein interactions and angles.

The paper uses myoglobin primary structure to identify convergent transitions to semi-aquatic life in Eulipotyphla mammals.

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

The paper shows that tree species richness stabilizes forest productivity through increased species asynchrony and hydraulic trait diversity, not community-weighted means.

This study determines the crystal structure of pDLA-88*001:01 and identifies its peptide-binding motif, revealing structural differences between two categories of DLA-88 alleles in dogs and their implications for antiviral immunity.

The paper identifies common genetic and structural features of human antibodies recognizing the influenza HA trimer interface, suggesting it as a target for vaccine design.

This study evaluates how broccoli sprouts and green tea polyphenols, alone or combined, affect gut microbiota and short-chain fatty acids in mice to prevent estrogen receptor-negative mammary cancer.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This paper develops a BSL-2 cell culture system for producing SARS-CoV-2 virus-like particles to enable safe antiviral screening and life cycle studies.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

This study examines how cigarette smoke and COPD affect SARS-CoV-2 infection by analyzing ACE2 and TMPRSS2 expression in human and mouse lung tissues and an in vitro model.

This paper shows that HPV evades cGAS/STING surveillance through unique vesicular trafficking, preventing cytosolic DNA detection and IFN responses.

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.

This study identifies two distinct oligomerization interfaces in Marburg virus VP40 that regulate lipid-specific protein oligomerization and matrix assembly at the plasma membrane.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

The paper uses molecular dynamics simulations to study how histone tails modulate nucleosome DNA accessibility and protein binding, revealing distinct binding modes and competitive interactions.

The paper identifies a novel ATP-dependent DMSP lysis pathway in bacteria, revealing a new route in the marine sulfur cycle through the enzyme AcoD.

This study shows seipin traps triacylglycerols in the ER membrane via its luminal hydrophobic helices, facilitating their nanoscale clustering and promoting TAG transfer to lipid droplets.

This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.

BioSamplr is an open-source, low-cost automated bioreactor sampling system that improves reproducibility and reduces hands-on time by enabling 24/7 sampling.

This paper shows that repeated Plasmodium falciparum infections reprogram human monocytes to a regulatory phenotype, reducing inflammatory responses during subsequent infections.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

The paper investigates how pore constrictions in pit membranes relate to embolism resistance in angiosperm xylem and finds that pit membrane thickness strongly influences constriction size and embolism resistance.

The paper shows that C. glabrata is inhibited by S. cerevisiae killer toxins despite resistance to antifungals.