S. Li

This study identifies PSGL-1 as an HIV restriction factor that inhibits HIV DNA synthesis and virion infectivity by restricting actin dynamics and sequestering HIV envelope proteins.

The paper examines the expression of SARS-CoV-2-related molecules in human tissues and immune cells across health and disease states, identifying age, comorbidities, and immune cell types associated with altered expression.

This study investigates the functional differences of kinesin-II in Chlamydomonas, showing that changes in IFT velocity have a limited effect on ciliary length.

This paper introduces SPD-NGS, a method using phage display libraries to deeply profile protease substrate specificity, identifying cleavage sites and natural substrates with high coverage and accuracy.

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

The paper uses 3-D imaging and computational analysis to show preferential obliteration of retinal secondary plexuses in hyperoxia-induced retinopathy.

The paper determines the cryo-EM structure of MtaLonA to elucidate its mechanism of ATP-powered substrate translocation.

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

This study quantifies the Zn uptake and distribution requirements needed to achieve high grain Zn concentration in high-yield wheat on low-Zn calcareous soils.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

This study investigates how aging impacts immune-myoblast communication during muscle repair, finding that old bone marrow impairs myogenesis by inhibiting myoblast proliferation.

This study shows senescent stromal cells release sEVs that promote cancer drug resistance via SIRT1 loss, and suggests targeting SIRT1 could prevent this resistance.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study develops an estrogen-inducible CRISPR/Cas9 system in Nicotiana tabacum and demonstrates its efficacy in inducing targeted mutagenesis of the NtPDS gene.

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

This paper introduces an amorphous nickel-titanium alloy film as a new supporting substrate for cryoEM, showing improved electron conductivity and reduced beam-induced motion, leading to better particle distribution and resolution.

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study investigates the effect of Dedu Safflower Powder on ascites hepatocarcinoma using H22 mouse models and identifies the miR-23a-DAPK1-PVT1 signal axis as a potential mechanism.

The paper analyzes longitudinal antibody responses to PfEMP1 CIDR domain variants and links specific IgG acquisitions to reduced risk of febrile malaria.

The paper investigates exosome-mediated apoptosis during WSSV infection in mud crabs, identifying miR-137 and miR-7847 as negative regulators of apoptosis by targeting AIF.

This study identifies splicing-dependent RNA-fusions in neuroblastoma and shows spliceosome inhibition reduces tumor growth.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

The paper constructs a nanobody library in mammalian cells using an ldsDNA-based AND gate genetic circuit, generating 22,173 unique sequences.

This study classifies RNase H-like domain-containing proteins in plants, identifying 27 clusters and highlighting their potential roles in DNA replication, RNA transcription, and nucleic acid degradation.

This study reports the crystal and cryo-EM structures of Ric-8A bound to Gαi1, revealing its mechanism of GTP exchange and chaperone activity through structural interactions.

The paper benchmarks predictive models for kinase inhibitor potencies using crowdsourced data and identifies new compound-kinase interactions.