X. Zhang

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

The paper shows that deleting all 3IgH CBEs affects germline transcription and CSR of upstream S regions, except S{gamma}1, and causes aberrant CSR rearrangements.

This study evaluates the effects of chronic bioelectric nerve stimulation on neuroskeletal health in diabetic rats, finding it does not prevent neuropathy or musculoskeletal complications but affects bone density and gait.

The paper investigates two fungal enterotoxins from Drechmeria coniospora and their distinct effects on the innate immune system of C. elegans.

This study identifies gene mutations in the PI3K/Akt pathway associated with immune thrombocytopenia (ITP) using whole-exome sequencing and functional analysis.

This paper develops a LAMP-based microfluidic chip for rapid, portable detection of Cryptococcus in CM, enabling visual, sample-to-answer diagnosis without additional instruments.

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

This study designs and tests RBD-conjugated nanoparticle vaccines against SARS-CoV-2, showing enhanced neutralizing activity compared to monomeric RBD.

The paper identifies PF-3845 as a novel inhibitor of Mycobacterium tuberculosis PheRS, showing selectivity over human PheRS and potential as an antibiotic lead.

This study identifies a new orthonairovirus, SGLV, associated with human febrile illness in northeastern China, showing its presence in ticks and clinical symptoms in infected patients.

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

The paper investigates photosynthesis-related gene expression in albino Artocarpus heterophyllus seedlings, finding down-regulated genes in pigment synthesis and photosynthesis pathways.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

The paper investigates the origin and timing of Denisovan introgression into Tibetans at the EPAS1 locus, finding an East Asian-specific introgression event around 43,000 years ago followed by selection 12,000 years ago.

The paper shows that serine phosphorylation of KdpB inhibits the KdpFABC potassium pump when K+ levels are restored, with mutations affecting pump activity.

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

This study shows that a ketogenic diet reduces inflammation and improves outcomes in aged mice infected with a coronavirus, suggesting potential therapeutic benefits for elderly COVID-19 patients.

This study identifies the ATAC histone acetyltransferase complex as an oncogenic driver in EHE by showing TAZ-CAMTA1 and YAP-TFE3 recruit it to modulate transcription and chromatin structure.

This paper introduces a method to determine in situ structures using single particle cryo-EM images without tilt series, improving efficiency and resolution.

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

This study shows the D614G mutation in SARS-CoV-2 increases viral replication and upper respiratory tract viral loads but does not reduce vaccine efficacy or antibody neutralization.

This study shows that MT1-MMP regulates tissue homeostasis via a non-proteolytic mechanism by controlling skeletal stem cell differentiation, independent of its proteolytic activity.

This study investigates how calcium ions bind to hyaluronan, reducing its chain rigidity through specific molecular interactions.

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

This study systematically optimizes cryo-EM parameters to routinely determine class B1 GPCR structures at better than 2.5 Å resolution.

The paper compares the binding and activation of the GLP-1 receptor by peptide and non-peptide agonists, revealing structural and functional differences that inform drug design.

This study identifies lineage transcription factors and super-enhancer signatures in SCLC, revealing co-regulation of subtype-specific genes and highlighting ASCL1 as a key dependency.