Y. Jiang

The paper identifies entangled misfolded states in all-atom protein folding simulations that resemble native states and are consistent with mass spectrometry data.

The paper identifies a latitudinal gradient in plant leaf-associated bacterial communities, showing host-driven selection at high latitudes and multiple factors at low latitudes.

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

This study uses GWAS to identify 277 candidate genes associated with adventitious rooting in Populus trichocarpa, highlighting roles in hormone signaling, cell division, and reactive oxygen species.

This study uses GWAS to identify candidate genes regulating in planta regeneration in Populus trichocarpa, finding over 200 genes involved in cell adhesion, stress signaling, and hormone pathways.

This paper develops a virtual liver needle biopsy method to quantify sampling bias in liver tissue, finding significant intra- and inter-needle variations in collagen proportionate area.

This study develops modRNA-based CRISPR systems for efficient genome editing in human pluripotent stem cells, achieving higher knockout efficiency than plasmid-based methods.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This study characterizes Brachypodium distachyon metabolomic responses to environmental changes using LC-MS/MS and identifies condition-specific metabolic biomarkers.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

The paper derives an analytical expression for condensate exchange timescales and shows interface resistance can arise from molecular bouncing at the droplet interface.

This study reports cryo-EM structures of NMUR1 and NMUR2 bound to NMU and NMS, revealing peptide selectivity mechanisms and activation principles for drug design.

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This study uses quantitative clonal tracing in mice to show that only a rare subset of distal fallopian tube cells can initiate and progress serous ovarian cancer.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

The paper shows that reduced rDNA stability in yeast leads to rRNA-binding protein aggregation, linking chromatin instability to proteostasis loss during aging.

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

The paper shows that misfolded proteins can bypass proteostasis by being structurally similar to native states and persisting for long periods.

This paper shows that synonymous mutations alter enzyme function over time by causing misfolded, entangled protein states that reduce catalytic activity.