Y. Jiang

This study shows that COVID-19 vaccination enhances the activation and redistribution of CD16brightCD56dim NK cells in Omicron BA.2-infected patients, improving clinical outcomes.

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

This study identifies the biosynthetic pathway for mitragynine and related alkaloids and uses it to enzymatically produce mitragynine, its epimer, and fluorinated analogues.

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

The paper creates a rumen virome database (RVD) and identifies 397,180 viral species-level OTUs, improving classification rates and revealing ecosystem impacts of rumen viruses.

This study investigates children's preference for using prototypes over analytical methods in scientific concept learning, finding a strong preference for prototype matching.

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

This paper develops STAMP-dCRISPR, a digital CRISPR-Cas13a method for amplification-free HIV-1 viral load quantification, showing high accuracy and speed comparable to RT-qPCR.

The paper presents cryo-EM structures of bombesin receptors bound to their neuropeptide ligands, revealing the mechanism of ligand selectivity and receptor activation for itch treatment.

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

This study investigates how excretory-secretory products from Echinococcus granulosus protoscoleces affect mouse hepatocyte growth, function, and glucose metabolism, finding inhibition of proliferation, promotion of apoptosis, and disruption of metabolic pathways.

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study determines the structural mechanism of a bacterial ZIP metal transporter, revealing an elevator-type transport mechanism through structural and computational analysis.

This study investigates the anti-hepatoblastoma effects of the compound AE-848, showing it inhibits cell proliferation, induces apoptosis, and reduces tumor growth in vivo.

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

This study presents cryo-EM structures of the PTH1R bound to various agonists, revealing how different peptides engage the receptor and providing insights for drug design.

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

The paper uses single-cell RNA-seq and ATAC-seq to analyze HIV latency reversal, identifying GATA3 as a novel regulator and demonstrating a machine learning model's predictive accuracy.

This study shows tegaserod maleate inhibits gastric cancer growth by targeting MEK1/2 in vitro and in a mouse model, with effects comparable to trametinib.

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.