Y. Jiang

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

The paper shows charged residues affect ribosome elongation speed through mechanochemical forces, supported by simulations and experimental data.

This study shows SARS-CoV-2 exploits sex-specific IFN and TNFα signaling to enhance ACE2 and TMPRSS2 expression in male alveolar cells, promoting viral entry and suggesting potential therapeutic targets.

This study shows that cyanophage PstS enhances host phosphate uptake and forms a chimeric ABC transporter with host proteins.

The paper identifies two long non-coding RNAs in the let-7 complex that induce cell death in Drosophila cancer cells and reduce tumor growth in vivo.

This study investigates ovule abortion in Paeonia ludlowii, identifying types, developmental stages, and morphological differences between aborted and fertile ovules.

The paper shows that the lncRNA let-A induces oncolytic cell death in human cancer cells but not in normal cells, requiring modification and Toll signaling for activity.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

The paper shows that differences in translation elongation rates between β- and γ-actin, due to their coding sequences, affect cell migration by altering actin dynamics and focal adhesion function.

The paper presents cryo-EM structures of MC1R-Gs complexes with ligands, revealing calcium's role in hormone recognition and Gβ interactions, and a conserved activation mechanism.

This study shows that (R)-NNAL promotes lung cancer progression by deactivating LKB1 through β-AR signaling, while (S)-NNAL has weaker effects.

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

The paper presents cryo-EM structures of the ghrelin receptor bound to ghrelin and GHRP-6, revealing the binding pocket for the octanoyl group and providing insights for drug design.

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

The paper reports structures of bradykinin receptors bound to their ligands and reveals mechanisms of selectivity and activation, providing insights for drug design.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

The paper investigates morphometric traits in hemp hybrids to identify predictors of biomass and cannabinoid yield, finding stem diameter and canopy architecture as key factors.

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study identifies SOX17 as a key factor for generating hemogenic endothelial progenitors from hPSCs using single-cell transcriptomics and functional assays.

This study identifies Tra1 as a key regulator of drug resistance and pathogenesis in Candida albicans by analyzing gene expression and mutant phenotypes.

This study shows that young and undamaged recombinant mouse serum albumin (rMSA) extends the lifespan and healthspan of C57BL/6N mice by 17.6% and 20.3% respectively.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

This study uses single-cell RNA sequencing to show that endothelial cells under laminar flow exhibit increased RNA heterogeneity but decreased protein heterogeneity.

This paper develops a 3D reconstruction method using ATUM-SEM and deep learning to analyze hepatic organelle interactions and their morphology.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

This paper develops a system to measure sub-second heat inactivation of coronavirus and identifies conditions achieving >5 Log10 viral titer reduction.

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.