Y. Ma

This paper develops an oral SARS-COV-2 RBD vaccine using LTB26 adjuvant in mice, showing enhanced antibody production and immune activation through DCs and B cells.

This study shows propionate activates endosomal Gi/p38 signaling via FFA2 to induce GLP-1 release in enteroendocrine cells.

This study investigates the effects of human umbilical cord mesenchymal stem cell transplantation on preserving and restoring fertility in aging and chemotherapy-damaged female mice.

The paper compares immune landscapes in transplant and primary tumors after immunotherapy and radiotherapy, finding that transplant tumors respond better due to CD8+ T cell enrichment.

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

This study shows that clustering of CD3ζ chains alone can initiate TCR signaling, including phosphorylation and calcium flux, in reconstituted cells.

This study demonstrates that cross-feeding between Thauera aminoaromatica and Rhodococcus pyridinivorans drives quinoline degradation in a denitrifying bioreactor through 2-hydroxyquinoline as an intermediate.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

This study finds that KALRN mutations enhance anti-tumor immunity and immunotherapy response in cancer by increasing tumor mutation burden and PD-L1 expression.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This study isolates and expands SOX9+ renal epithelial cells from adult humans, showing their ability to regenerate kidney tissue in mice.

This paper isolates and characterizes a Rhodopseudomonas palustris strain capable of anaerobically degrading syringic acid, revealing a novel metabolic pathway distinct from the benzoyl-CoA degradation pathway.

This study identifies human lncRNA metabolic regulators (hLMRs) using integrative transcriptome analyses and humanized mouse models, validating one hLMR's role in cholesterol metabolism.

The paper identifies specific gyrA gene mutations in Mycobacterium tuberculosis isolates that cause discordant levofloxacin resistance between molecular and phenotypic testing.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

This study compares the effects of 1-propanol and 2-propanol on DNA structure using fluorescence microscopy and CD measurements, showing different conformational transitions and secondary structure changes.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

The paper induces AvrRps4 expression in Arabidopsis to study RRS1/RPS4-mediated immunity without pathogen presence, revealing downstream immune responses.

This study evaluates the prognostic role of c-Met overexpression in high-grade glioma through meta-analysis and finds it correlates with poor progression-free survival but not overall survival.

This paper identifies the molecular mechanism by which plant receptor kinases GSO1/SGN3 and GSO2 recognize sequence-divergent CIF peptides through structural and biochemical analyses.

The paper examines how influenza virus type and vaccination status influence nasopharyngeal microbiota composition in infected individuals and healthy controls.

The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.

This study shows WUSCHEL regulates auxin signaling to maintain apical stem cells in Arabidopsis by controlling histone acetylation and balancing differentiation.

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

This paper designs treatment schedules using evolutionary game theory to avoid chemotherapeutic resistance by maintaining population balance through periodic dose switching.

This study uses a replicator dynamical system to show that pre-existing resistant cells lead to chemotherapeutic resistance through competitive release.

The paper uses proteomic analysis to study protein dynamics in mouse cardiac remodeling, identifying adaptive and maladaptive changes and their underlying mechanisms.