Y. Ma

This paper evaluates the robustness of adaptive chemotherapy schedules using a stochastic evolutionary game theory model and finds that error distributions grow exponentially with treatment cycles, leading to treatment failure.

This study shows GM-CSF is critical for mitochondrial function and metabolism in macrophages, supporting their proliferation and self-renewal.

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

The paper identifies immune escape mutations in influenza A virus HA-tag linear epitopes and proposes establishing an IEMM library to address vaccine challenges.

This study shows that bacteria in the rectum of male oriental fruit flies produce sex pheromones, specifically TMP and TTMP, which attract females.

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

The paper identifies two independent parental contributions to zygote polarization in Arabidopsis thaliana, involving maternal ERECTA and paternal SHORT SUSPENSOR (SSP) in activating the YDA MAP kinase pathway.

The paper introduces Pumas, a high-performance platform for pharmacometric modeling, showing significant performance improvements in drug development and precision medicine.

The paper investigates the role of miR-129-5p in reversing CCl4-induced hepatic fibrosis by targeting PEG3 and the NF-κB pathway, though the manuscript has been withdrawn.

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

This study identifies a new metabolic pathway in Novosphingobium aromaticivorans for converting phenolic compounds into 2-pyrone-4,6-dicarboxylic acid, improving strain engineering for lignin valorization.

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

This study identifies function-specific sites in vertebrate neuronal nAChR subunits through evolutionary analysis, revealing unique selection pressures and potential positive selection events.

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

This paper investigates how Na+ flux through DISP1 enables release of lipid-modified Hedgehog signals by analyzing structural and functional changes in DISP1 variants.

This study shows that deleting Atm in p53-deficient brainstem gliomas enhances radiosensitivity, while p53 wild-type tumors respond to radiotherapy regardless of Atm status.

This study shows that PYY3-36's physiological effects on food intake depend on the vagus nerve's Y2R, but pharmacological effects are not affected.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.

This study investigates L-arabinose's antifeedant effects on cotton bollworm caterpillars, showing it deters feeding, suppresses gustatory responses, and inhibits sucrase activity.

This paper introduces compressed FLIM for high-speed, high-resolution live-cell imaging, achieving 100 Hz imaging with reduced photobleaching and motion artifacts.

This paper develops an optimal control theory to maximize cooperation in the prisoner's dilemma game by dynamically adjusting payoffs over time, with applications in evolutionary biology and related fields.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

IsoMaTrix visualizes isoclines of matrix games and quantifies uncertainty in structured populations, showing spatial configuration impacts cancer model dynamics under treatment.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

This paper develops an evolutionary game theory model to design two-drug adaptive chemotherapy schedules that mitigate chemoresistance by leveraging antagonistic drug interactions.

This study investigates how phytochromes in Agrobacterium fabrum affect DNA transfer, growth, swimming, and interbacterial competition, distinguishing light-regulated and light-independent responses.

This study compares non-Cochrane nursing systematic reviews with their PROSPERO-registered protocols, finding widespread discrepancies with few explanations.