Y. Wang

This paper introduces a new plant transformation method called RAPID that achieves high efficiency and speed without tissue culture.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

This study shows engineered graphene quantum dots inhibit and disassemble tau protein aggregates in vitro, suggesting their potential as a treatment for tauopathies.

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

This paper introduces a DNA origami-based method for steric communication between dynamic components, demonstrating signal transmission through thermal fluctuations and conformational regulation.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

This study observes immune system changes in rat urine proteome after immunization with bovine serum albumin and aluminum hydroxide adjuvant.

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

This study identifies disruption of the nuclear localization signal in RBM20 as a causative mechanism in dilated cardiomyopathy through impaired nucleocytoplasmic transport.

The paper introduces SMRT-AgRenSeq-d, a method for identifying NLR resistance genes in potato, and applies it to find nine strong candidates for the nematode resistance gene Gpa5.

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

This study compares mutational spectra in biofilms of two Bacillus species under abiotic and biotic conditions, finding that smaller population sizes and biotic environments lead to higher mutation rates and diversity.

A CXCR3-activating peptide improves tear quality and reduces corneal haze in a rabbit model of environmental dry eye without affecting tear volume.

This paper demonstrates that heat-killed fbp1 mutant cells (HK-fbp1) can protect against lethal Cryptococcus neoformans infection as both a prophylactic vaccine and a therapeutic agent, with T cells mediating protection and early treatment being critical.

This study determines the cryo-EM structure of AMBRA1 bound to DDB1, revealing how AMBRA1 recruits substrates for ubiquitination and its role in autophagy and cell-cycle regulation.

The paper uses satellite data to show rubber expansion caused more deforestation in Southeast Asia than previously estimated, highlighting the need for updated policies.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.

This study identifies DNA damage patterns across tissues and sexes in rodents and humans, revealing age- and sex-dependent variations in DNA adducts and their potential as disease markers.

This study determines the structure of the Na+-driven bacterial flagellar stator unit PomAB, revealing mechanisms of ion selectivity, rotor coupling, and stator unit activation.

This study shows that LNP-based vaccines induce time- and dose-dependent anti-PEG antibodies in rats, with immune memory and accelerated blood clearance upon re-injection.

This paper validates and optimizes a divide-and-conquer procedure for quantum refinement of biomolecular structures, introducing an error score to guide computational efficiency.

The paper investigates miR-210-3p as a hypoxia marker in anaplastic thyroid cancer cells, showing its expression under low oxygen conditions and association with extracellular vesicles and AGO2.

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

The paper identifies a lncRNA, TREX, as a biomarker predicting in vivo efficacy of RPE cell transplantation and shows its impact on cell integration.

The paper identifies two Keap1 isoforms that interact with Smad2/3, enhancing their stability and transcriptional activity, and reveals a novel crosstalk between the Keap1-Nrf2 and TGF-β1-Smad2/3 pathways.