Y. Wang

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

The paper shows gut microbiota regulate complement component 3 (C3) production in humans and mice, with intestinal C3 levels correlating with protection against enteric infections.

This study identifies a unique GSH utilization pathway in Francisella, revealing a pseudogenized transporter gene in pathogenic strains and its role in environmental niches.

This study compares how mutations in α-catenin's M-domain and FABD affect epithelial strength and migration by analyzing cell behavior and protein interactions.

This study shows that C9orf72 hexanucleotide repeat expansions form RNA condensates via multimolecular G-quadruplexes, suggesting a therapeutic target for ALS/FTD.

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

The paper shows that Hap43, an iron-responsive transcription factor, is degraded under high iron conditions in C. albicans, leading to antioxidant gene activation and enhanced gut colonization.

This study evaluates an attenuated Chlamydia muridarum mutant as an oral vaccine that induces transmucosal immunity against genital and airway infections but not gastrointestinal colonization.

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

This study shows that Wg signaling reduces lipid accumulation in Drosophila adipocytes by repressing lipogenesis and fatty acid β-oxidation while promoting lipolysis.

This study shows that indole, a gut microbe metabolite, is essential for maintaining organ function and metabolic homeostasis, and its deficiency leads to multiorgan decline and accelerated biological ageing.

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

This study reports the first complete mitochondrial genome of Strix aluco, identifies its divergence time, and links geographic and climatic factors to its speciation.

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

The paper shows that CpG ODNs interact with mitochondrial VDAC1 to induce antimicrobial ROS in lung epithelial cells, offering a new therapeutic strategy for pneumonia without antibiotics.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study reveals that AcrIIC5 mimics dsDNA to inhibit type II-C Cas9 by blocking PAM recognition, providing insights into its mechanism and evolutionary convergence.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.

This study identifies HEV-ORF3 as a prion-like protein that facilitates virion release and pathogenesis by forming filamentous structures, highlighting its role in viral assembly.

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

This study identifies tissue-specific and state-dependent sex differences in metabolomes of mouse eye and brain tissues under fed and fasted conditions.

This study compares four statistical methods for fitting Poisson point processes to presence data, finding the Berman-Turner device most consistent, and applies it to predict the distribution of an invasive weed.

The paper analyzes SARS-CoV-2 envelope protein mutations across Omicron sub-variants to assess their impact on pathogenicity, finding that certain mutations correlate with reduced disease severity.

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

This study identifies Calponin 2's role in kidney fibrosis by linking cellular mechanics to metabolic reprogramming via fatty acid oxidation regulation.