Y. Yin

This paper develops a CAR T cell with broad EGFR specificity to target multiple tumor clones and reduce antigen loss escape in glioblastoma.

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

Microbe-seq enables strain-resolved genome reconstruction from complex microbial communities, revealing intra-phylum horizontal gene transfer and bacteriophage-bacterial associations in the human gut.

This study uses directed evolution to identify SH2 domain variants with enhanced binding to phosphotyrosine peptides, revealing differences in cross-reactivity with sulfotyrosine.

This study integrates multi-omic data to construct a regulatory network of brassinosteroid response in Arabidopsis, identifying key phosphorylation sites and a novel transcription factor involved in cell division.

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

This study shows that enhanced RNA-directed DNA methylation (RdDM) in reproductive organs increases DNA methylation, ensuring sexual reproduction in rice by regulating gene expression.

This study identifies a rare case where closely related fungi produce structurally distinct beauveriolide analogs, challenging fungal chemotaxonomy and revealing insights into BGC evolution and virulence.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

The paper introduces RoAD, a robotic system for automated BR and drought response experiments in Arabidopsis and maize, using imaging and machine learning to measure plant traits.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

The paper systematically analyzes correlations between 221 physical examination indicators in healthy and disease states, identifies disease markers, and develops machine learning models to predict health status with high precision.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study reports cryo-EM structures of TRPM2 channel in intermediate states to elucidate structural transitions during ligand-dependent gating.

This study shows chronic stress increases oxytocin levels, which promotes melanoma metastasis via β-arrestin 2-dependent pathways, suggesting OXT as a therapeutic target.

This study investigates nasal immune responses in rainbow trout to Ichthyophthirius multifiliis infection, finding parasite-specific IgT production and B-cell proliferation in the nasal mucosa.

The paper identifies two distinct DNA sequences recognized by transcription factors as enthalpy and entropy optima, revealing how thermodynamic factors influence binding affinity.

The paper shows that mast cell-derived extracellular vesicles carrying TGFβ-1 enhance mesenchymal stem cell migration and MMP activity, with endosomal retention prolonging TGFβ-1 signaling and reducing allergic inflammation.