Y. Zheng

This study shows that Aβ from AD neurons activates endothelial cells, causing inflammation and thrombosis in a human brain microvessel model.

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

The paper shows that topological defects in cellular swirl patterns predict cartilage differentiation potential of mesenchymal stromal cells.

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

This study identifies the WNT5A-RHOA axis as a critical driver of small-cell lung cancer, offering new therapeutic targets and insights into WNT signaling heterogeneity.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

This study examines prostate cancer progression at single-cell resolution, identifying castration-resistant luminal cells and their role in treatment resistance and tumor heterogeneity.

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

The paper models the evolution of tandem gene arrays under recombination and selection, showing how copy number distribution and fitness depend on these factors and demographic parameters.

The paper analyzes the expansion and adaptive evolution of mTERF genes in plants, finding that M-class mTERF genes expanded via tandem duplication and evolved rapidly with positive selection in nucleic acid-binding sites.

The paper develops a high-throughput method to screen restriction endonucleases using microfluidics and bacterial SOS response, achieving 30-fold enrichment of target genes in one hour.

The paper shows lamin C, BAF, and cGAS accumulate at nuclear envelope rupture sites in mouse cells, with lamin A/C involvement in DNA sensing.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

The paper analyzes small RNA expression dynamics in tomato accessions to show how genomic structural variants influence different small RNA classes and their selection pressures during domestication.

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

This study identifies ADAP1 as a factor that enhances T cell signaling and promotes HIV-1 reactivation by modulating the ERK-AP-1 axis.

This paper introduces a CRISPR-nCas3 system for efficient genome editing in bacteria, enabling high-efficiency deletion of large genomic regions.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

This study develops a far-red probe and microfluidic platform to image live erythrocyte membranes at the single-molecule level, enabling high-throughput super-resolution and tracking.

The paper identifies DCA as a CDK8 inhibitor that induces a tolerogenic immunophenotype in CD4+ T cells through a novel CDK8-GATA3-FOXP3 pathway, promoting Treg and Th2 differentiation while inhibiting Th1 and Th17.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows that Amot is essential for vascular expansion by transmitting mechanical forces through the integrin adhesome in mice.

This study shows pepper activates two different immune systems against Ralstonia solanacearum under high temperature and humidity, regulated by CaWRKY40 and cytokinins.

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.