Z. Li

This study predicts post-mining land use in the Hongliulin mining area using random forest and DBSCAN, achieving 95% classification accuracy with 1 miss-classified sample.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

This study investigates how mono-phosphorylation at Ser4 of Banf1 disrupts its DNA binding by altering its conformation and binding surface through molecular modeling and simulations.

The paper identifies a 78-gene prognostic signature for lung adenocarcinoma that correlates with cell cycle activity and treatment response to PIM inhibitors.

The paper develops a method to track transcriptome differences in clonal expansion and shows constrained expression noise dynamics during cell divisions.

This study investigates how oxidative stress and reperfusion injury affect desmin proteostasis, identifying mechanisms to reduce toxic desmin aggregates and improve cardiac function.

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

This study optimizes MP isolation protocols, identifies 3000g as critical for composition, and reveals functional differences between traditional and new MPs.

This study investigates the conformational transition of STING upon cGAMP binding, identifying mutations that affect the energetic landscape and suggesting V147L may not be a gain-of-function mutation.

This paper develops and validates a high-throughput system for long-term optical measurement of peri-cellular oxygen in cardiac cells, showing dynamic oxygen changes and differences between hiPSC-CMs and fibroblasts.

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

This study shows that sialoglycan binding triggers the opening of the spike protein in the human coronavirus HKU1 through allosteric inter-domain cross-talk.

The paper analyzes metatranscriptomic data from Antarctic diatoms to identify molecular strategies that contribute to their ecological success in varying environmental conditions.

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

This study identifies Malat1 as a regulator of miR-15/16 in cytotoxic T cells, showing that disrupting their interaction impairs T cell activation and memory formation.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study screens six non-antibiotic growth promoter combinations in vitro to improve feed efficiency and broiler health by evaluating digestibility, microbiota, and antioxidant capacity.

The paper proposes a lightweight fine-tuning method for pretrained protein language models to improve secondary structure prediction performance.

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

The paper identifies an immunometabolic pathway in dendritic cells that limits autoimmunity and develops a synthetic probiotic to activate this pathway.

The paper identifies two molecular subtypes of lung adenocarcinoma using multi-omics data and develops a signature to predict immunotherapy response.

This study shows that galactosylated glycoproteins from bovine milk inhibit both SARS-CoV-2 and influenza virus by blocking their interaction with ACE2.

This study identifies PCNA's role in temperature stress tolerance of Ulva prolifera, showing its interaction with CyclinA and regulation by miR-2916 through the MAPK pathway.

This study investigates the hierarchical dynamics of TNP1-DNA interactions using computational and experimental methods to understand DNA condensation and its implications for vaccine design.

This study shows that total sphingomyelin synthase (SMS) deficiency reduces LDL receptors and impairs LDL catabolism in mice, while SMS2 deficiency does not have this effect.

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.