B. Liu

The paper identifies ALPPL2 as a highly specific tumor cell surface antigen for mesothelioma and demonstrates its therapeutic potential through an antibody-drug conjugate.

This study identifies cinnamoyl-CoA reductases (CCR) as benzaldehyde synthases in cucumber, showing their specific expression and enzymatic activity in roots and flowers.

This study introduces a modular method to generate bispecific and multi-specific antibodies using temporary linkers and proteases, enabling efficient production with desired properties.

This study evaluates enzalutamide's efficacy and resistance development in a mouse model of type-I endometrial carcinoma, finding it reduces tumor burden initially but promotes resistance with prolonged use.

The paper investigates mechanisms of EGFR-TKI resistance in NSCLC, showing HER2/HER3 activation and cyclin D1 upregulation contribute to cell survival and resistance.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This study shows that m6A modification in HIV-1 RRE stem IIB has minimal effects on structure, dynamics, and Rev ARM binding.

This study identifies differentially expressed genes and pathways in Botrytis cinerea treated with wuyiencin, revealing its impact on metabolism, protein synthesis, and cell growth.

This study shows that the PAR2 signal peptide prevents premature receptor cleavage and activation by intracellular proteases, ensuring proper cell surface expression and ligand response.

This study shows that administering specialized pro-resolving mediators (SPMs) reduces inflammation and improves recovery in mice exposed to chemical skin injuries.

This study identifies VCAP1 as a key protein controlling Maurer’s cleft structure and PfEMP1 trafficking in Plasmodium falciparum, leading to altered parasite growth and RBC deformability.

The paper shows that the DNMT3A Arg882His variant in AML acquires DNMT3B-like substrate preference, potentially contributing to its oncogenic effect.

The paper introduces a modular fluorescence microscope with flexible illumination and imaging modes, demonstrating its use in biosensor imaging, optogenetics, and 3D volume imaging.

This paper develops an intravenous pentamidine formulation using Pluronic micelles to enhance CNS exposure for stage 2 HAT treatment, finding no major neurotoxicity but limited BBB penetration enhancement.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

This paper introduces a simple method to co-purify genomic DNA, RNA, and proteins from the same samples, reducing precipitation steps and enabling high-throughput analyses.

The paper identifies TPXL3 as the primary activator of α Aurora kinases in Arabidopsis, essential for embryogenesis, while TPX2 and TPXL2 have distinct roles.

This study identifies a mechanism by which Unc93b1 recruits Syntenin-1 to specifically inhibit TLR7 signaling and prevent autoimmunity.

This paper identifies Gp5.7 as a T7 phage protein that inhibits EσS in stationary phase E. coli, enabling T7 development in both exponential and stationary growth phases.

This study examines how elevated CO2 affects the development and food utilization of Mythimna separata larvae feeding on Bt maize infected with nitrogen-fixing bacteria.

The paper profiles sgRNA activity in E. coli to improve CRISPR/Cas9 efficiency and identifies limitations of existing prediction models.

This study identifies OsKCH2 as a processive minus-end-directed kinesin-14 in plants, compensating for the absence of cytoplasmic dynein.

This study uses 18F-FDG PET/CT imaging and molecular assays to assess BAT aging in LmnaG609G/G609G mice, finding reduced metabolic activity and increased apoptosis/senescence compared to wild-type mice.

This study shows that mechanical loading at different stages of cortical bone healing affects repair outcomes, with loading during matrix deposition enhancing bone and cartilage formation.

This study shows estrogen protects against intervertebral disc degeneration by upregulating ER, but miR-221 reduces this protection by targeting ER.

This paper identifies HpaM, a novel FAD-dependent monooxygenase in Alcaligenes faecalis JQ135, which catalyzes 2-decarboxylative hydroxylation of 5HPA to produce 2,5-DPH.

This paper develops a CRISPRi library for high-throughput functional genomics in E. coli, identifies sgRNA design rules, and validates gene-phenotype associations with high specificity.

This paper introduces a method to visualize the cell-material interface at nanometer resolution using FIB-SEM, enabling detailed study of cell-material interactions.