B. Zhang

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

The paper identifies a novel ER-to-nucleus signaling pathway mediated by iRhom2 cleavage by the signal peptidase complex, linking it to psoriasis and TOC.

This study identifies Rnf as the key enzyme for propionate formation in Prevotella species via the succinate pathway, supported by genomic, proteomic, and enzymatic analyses.

The paper introduces a kinetic model to study how chromatin folding and histone modifications influence epigenetic stability through dynamic asymmetry.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

The paper describes the Children's Brain Tumor Network (CBTN), a consortium that collects and shares multi-omic data and biospecimens to advance research on pediatric brain tumors.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

This paper identifies a broadly neutralizing antibody from a snakebite survivor that protects against multiple snake venoms by targeting conserved neurotoxin epitopes.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

This study investigates the distinct roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of factor V and factor VIII, revealing that MCFD2 binds cargo and LMAN1 acts as a shuttling carrier.

This study identifies novel genes and regulatory elements associated with drought tolerance in common bean by analyzing transpiration responses and performing genome-wide association analyses.

Hourglass processes bioimaging data to reveal sex-specific IL-6 effects on T cell responses in pancreatic tumors.

This study uses a near atomistic model to show that chromatin fibers break into clutches and trimers/tetramers under tension, supporting a hypothesis of in vivo chromatin configurations as folding intermediates.

This study develops molecular markers for KTI mutant alleles in soybean using CRISPR/Cas9 to aid in breeding low TI trait cultivars.

This study derives a theoretical framework for co-segregation probability from genome architecture mapping and shows that normalization with many nuclear slices improves correlation with inter-locus distances.

This study shows that CMA deficiency in mesenchymal cancers promotes tumor growth via TGFβ signaling and metabolic rewiring.

The paper shows that extravascular spaces, not the bloodstream, are the main source of antigenic diversity in Trypanosoma brucei infections, with over 75% of VSGs found exclusively in these spaces.

This paper identifies a novel C. elegans pathway involving nck-1 and the actin cytoskeleton that mediates defense against bacterial pore-forming proteins, independent of MAPK signaling.

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

This study simulates the human genome using active forces to show their impact on heterochromatin localization and long-range spatial correlations.

This study shows that insulin receptor loss delays mammary tumor onset and burden in mouse models, without affecting progression or metastasis.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

The paper introduces cgRNASP, a series of coarse-grained statistical potentials for RNA 3D structure evaluation, showing comparable or better performance than all-atom methods with higher efficiency.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study shows that disrupting the FabH gene in E. coli reduces its resistance to antibiotics by compromising the cell envelope, making previously ineffective antibiotics effective again.

The paper presents high-resolution cryo-EM structures of the full-length human AE1 transporter in various states, revealing substrate binding, inhibition mechanisms, and lipid/sterol binding sites.