B. Zhang

The paper identifies core bacterial taxa and mobile genetic elements associated with extracellular antibiotic resistance genes in water compartments.

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

This study identifies that PGE2-EP2 signaling suppresses lung ILC2 responses and eosinophilic inflammation, while EP4 agonism restricts these responses, offering potential therapeutic targets for asthma and NERD.

This paper introduces and validates a DESS wipe-based method for stool collection and preservation, showing high accuracy and diversity maintenance compared to freezing and commercial kits.

This study uses polymer simulations to model how the diploid human genome organizes relative to nuclear bodies, showing that co-phase separation explains genome compartmentalization and spatial arrangement.

This study shows that prolonged heterochronic parabiosis reduces biological age and extends lifespan in mice through long-term epigenetic and transcriptomic changes.

This paper derives analytic expressions to predict multi-way chromatin contacts from Hi-C data, showing good correlation with experimental measurements.

This study shows ligand binding causes intracellular conformational changes in monomeric EGFR, linking extracellular and intracellular regions through the transmembrane helix.

This paper identifies a novel pectin from Syzygium aromaticum that strongly inhibits SARS-CoV-2 replication by binding to 3CLpro, PLpro, and RdRp enzymes.

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

This study identifies ten Shaker K+ channel genes in foxtail millet and analyzes their expression under abiotic stresses and ABA treatment, revealing distinct regulation patterns.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

This study uses near-atomistic simulations to investigate the stability and layered organization of protein-DNA condensates, revealing how protein-DNA ratios and interactions influence their structure.

The paper introduces a 4D subtractive manufacturing technique to create perfusable complex tissues in multi-well plates, enabling the fabrication of vascular networks and organ-specific structures.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study shows that altering GIGANTEA gene expression in Populus affects leaf senescence through two distinct mechanisms, independent of FT expression and environmental conditions.

This paper identifies aCPSF1 and terminator U-tract synergy in archaeal transcription termination, showing their roles in determining termination efficiency through KH domain binding and nuclease activity.

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

This study shows that a common SEC23B mutation in mice causes chronic pancreatitis and growth restriction, highlighting SEC23B's role in pancreatic function and growth hormone sensitivity.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

This study examines how simulated microgravity affects biofilm formation in Proteus mirabilis and identifies gene expression changes linked to reduced biofilm formation.

This study investigates how linker histone H1 interacts with single-stranded DNA, revealing coacervation and phase separation mechanisms.

The paper uses simulations to study how chromatin networks affect droplet formation and coalescence in nuclei, finding that protein-chromatin interactions stabilize multi-droplet states.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.