D. Wang

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

This study tracks T cell dynamics in a glioblastoma patient undergoing CAR T cell therapy, showing endogenous T cells are activated and contribute to treatment response.

This study shows that necroptosis increases with age in the liver, contributing to chronic inflammation and fibrosis.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

The paper analyzes RNASeq data from a Pax3-expressing myoblast clone to investigate how culture surface stiffness affects differentiation, finding enhanced myogenic gene expression on softer surfaces.

This study shows that the intracellular glycosyl hydrolase PslG affects signaling, ePsl structure, cyclic-di-GMP levels, and biofilm formation in Pseudomonas aeruginosa.

The paper defines single-cell trajectories and identifies chromatin regulators that establish antiviral CD8 T cell heterogeneity during acute and chronic infections.

This study uses multi-omics approaches to identify regulators of CD38 surface expression in multiple myeloma and assess the impact of therapies on CD38 levels and signaling.

The paper identifies a core miRNA network that originated in placental mammals and explains the evolution of placenta and diverse pregnancy strategies.

This study shows that isonicotinamide (INAM) extends yeast chronological lifespan by inhibiting nucleotide salvage pathways, leading to NAD+ accumulation and a hormetic stress response.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

The paper investigates how gravitation stress affects the transmembrane potential in toad bladder urothelium, showing increased chloride channel activity and altered ion permeability.

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

The paper discovers new crAss-like phage species and explores their diversity, genomic features, host associations, and links to human health phenotypes in Dutch gut metagenomes.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

The study examines the fitness costs of female mate choice in zebra finches, finding that high competition does not reduce fitness due to alternative reproductive tactics.

The paper identifies an antibody that neutralizes all SARS-CoV-2 variants by targeting a conserved epitope on the spike protein.

This study examines how long-term tea monoculture affects soil nutrient dynamics and bacterial communities across different stand ages.

This study examines how simulated microgravity affects biofilm formation in Proteus mirabilis and identifies gene expression changes linked to reduced biofilm formation.

This study identifies CDK7 as a therapeutic target in Myc-driven medulloblastoma, showing that its inhibition sensitizes tumors to radiation.

This study determines the cryo-EM structure of HCMV Pentamer bound to neuropilin 2 and neutralizing antibodies, revealing molecular interactions and epitopes involved in viral tropism and neutralization.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This paper develops OPROTACs, programmable molecules that degrade DNA-binding proteins like ERG and LEF1, showing potential for targeting undruggable transcription factors in cancer.

This paper investigates the regulation of the HigBHigA toxin-antitoxin pair from plasmid Rts1 in Proteus vulgaris, finding it functions as an on/off transcriptional switch rather than a molecular rheostat.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

The paper identifies bacterial structural variants associated with bile acid metabolism in humans using metagenomic data from two Dutch cohorts.