F. Liu

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.

This study compares blood flow dynamics in a diseased left circumflex artery and its artificially restored version to identify flow characteristics linked to coronary artery disease risk.

The paper uses a two-step molecular approach to delimit species in the spider genus Heptathela, identifying 20 putative species from 180 sampled individuals.

This study improves cross-link identification in XL-MS by using FAIMS to enhance separation and sensitivity, increasing identification rates by 23-56%.

This study shows that knocking down both miR-21 and CXCR4 inhibits glioma progression more effectively than single-targeted knockdown, by suppressing PI3K/AKT and Raf/MEK/ERK pathways.

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

The paper analyzes transcriptomic and proteomic data from a new cytoplasmic male sterile cotton line to identify differentially expressed genes and proteins involved in microspore abortion.

This study shows SPARC enhances insulin secretion by reducing RGS4 in pancreatic beta-cells, improving glucose tolerance in SPARC-deficient mice.

This paper develops a mechanochemical model to study how cell tension affects migration, showing it inhibits movement under persistent stimuli but can enhance migration under random noise.

The paper shows that mRNA transcripts for sodium and potassium channels form complexes during translation, coordinating their expression to regulate cardiac electrical activity.

The paper analyzes ancient DNA from museum specimens to show that Southern Chinese gray wolves form a distinct sub-population with genetic links to an extinct canid related to dholes.

This study identifies differentially expressed genes and pathways in small yellow croaker liver under heat and cold stress, providing insights into temperature stress responses for aquaculture improvement.

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

This study shows that nutrient-stimulated histone acetylation regulates the islet epigenome to control adaptive insulin secretion, with Lsd1 playing a key role in this process.

This study shows HIV-1 Nef interacts with LMP7 to reduce immunoproteasome formation and MHC-I antigen presentation, aiding viral immune evasion.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

This study identifies α-tubulin in Laodelphax striatellus as a facilitator of rice stripe virus (RSV) passage through midgut and salivary glands, enhancing horizontal transmission.

This study uses in vivo proteomics and nutrient tracing to show age-related metabolic changes in pancreatic β-cells improve glucose-stimulated insulin secretion.

The paper identifies the raxX-raxSTAB gene cluster in Xanthomonas species and shows its role in RaxX peptide production, which is required for XA21-mediated immunity but not for peptide hormone activity.

The paper introduces an M-value to quantify mitochondria-lysosome contact and mitophagy using structured illumination microscopy, finding distinct M-value ranges for these processes.

The paper develops an iridium(III) dye for tracking mitochondrial dynamics under structured illumination microscopy, revealing new insights into mitochondria-lysosome interactions.

The paper shows that expressing a chimeric receptor with XA21 ectodomain and EFR endodomain in rice confers resistance to Xoo, indicating the ectodomain is key for robust resistance.