J. Shi

This study shows that stabilizing the HIV-1 capsid with IP6 or HCB enhances reverse transcription efficiency in vitro by maintaining the association of CA and RT proteins with viral cores.

This study uses DNA-origami NPC mimics to show HIV-1 capsid uses a trimeric interface and RRR motif to pass through nuclear pores, bypassing the FG motif of NUP153.

This study identifies Rac1/ROCK-driven membrane dynamics as a mechanism promoting necroptosis in NK cell cytotoxicity, enhancing target selectivity in cancer.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

This paper investigates how fentanyl activates the mu-opioid receptor through beta-arrestin biased signaling using molecular dynamics simulations and validates findings with synthesized compounds.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

The paper investigates functional convergence in human antibody repertoires by analyzing structural commonality in baseline and response antibodies, finding high structural similarity across individuals.

This study shows that the C-linker in BK channels modulates activation through nonspecific membrane interactions, challenging previous assumptions about its role.

The paper compares transcription, histone acetylation, and macromolecular packing in proliferating and quiescent G0 fission yeast nuclei using cytological and biochemical methods.

This study uses single-cell RNA sequencing to characterize mouse epididymal cell types and their gene expression profiles, identifying seven known and two novel cell populations along with region-specific gene expression signatures.

This study identifies genes that modulate cellular plasticity and influence therapy resistance in cancer cells through CRISPR screens, showing that manipulating plasticity before therapy can alter resistance.

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

Thera-SAbDab tracks therapeutic antibodies and nanobodies, linking them to structural data and metadata for sequence and target analysis.

This study determines the structure of an E. coli transcription activation complex and shows that Crl stabilizes σS to activate transcription without DNA contact.

This study develops an efficient CRISPR/Cas9 method for integrating a large transgene cassette into the CEP112 locus in pigs, achieving successful expression of microbial enzymes in salivary glands.

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

The paper uses MD simulations to study ligand transport by P-gp and shows lipids also play a role in this process.

The paper develops GenEPi, a fluorescent reporter for visualizing mechanical stimuli based on Piezo1, demonstrating high specificity and spatiotemporal resolution in live tissues.

This study investigates lipid interactions of PC2 using simulations and cryo-EM, identifying PIP and cholesterol binding sites.

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study examines genome damage in rice and maize after biolistic transformation, finding that some events result in large-scale chromosomal alterations and repair via homology-dependent mechanisms.

The paper introduces TAP, a tool that identifies developability issues in therapeutic antibodies using five computational guidelines based on structural and charge properties.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.

This study identifies HNF1A as a central regulator of pancreatic cancer stem cells and a novel oncogene in pancreatic ductal adenocarcinoma.