J. Shi

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

This study presents a droplet microfluidic assay to assess CAR-T cytotoxicity in vitro, enabling analysis of activity, expansion, and mechanism under varying conditions.

The paper applies deep learning to identify anther dehiscence states in cotton to screen for heat-tolerant varieties and support genetic breeding research.

This study identifies a metabolic switch in mast cells driven by mTORC1 and Slc37a2 that enables regranulation after degranulation.

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.

This study shows that an HIV-1 mutation escaping CTL response impairs viral DNA integration, and compensatory mutations or host factors can rescue this defect.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This paper demonstrates the chemical synthesis of knob domain antibody fragments, showing structural equivalence to biological products and highlighting methods to improve their stability and efficacy.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

This study shows benzydamine enhances tetracycline antibiotics' effectiveness against drug-resistant bacteria by disrupting membrane potential and increasing drug uptake.

The paper uses cryo-ET to analyze budding yeast meiosis and finds meiotic triple helices (MTHs) instead of expected synaptonemal complexes.

This study shows that loss of ATF3 reduces pancreatic cancer progression by limiting acinar-to-ductal metaplasia and enhancing regeneration, but KRASG12D can bypass ATF3's requirement in some contexts.

The paper shows that facilitation between salt marsh grass and mussels creates spatial patterns on salt marsh shorelines.

The paper identifies O-glycosylation sites on SARS-CoV-2 spike protein and shows that host O-glycosyltransferase ppGalNAc-T6 enhances its trimeric structure stability through increased glycosylation.

This study uses cryo-ET to show that most nucleosomes in yeast cells are non-canonical, challenging previous assumptions about their structure.

This study computationally reconstructs the full-length Piezo1 structure, revealing its trilobed topology, lipid interactions, and how membrane stiffness affects its shape.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

This study identifies FLK as a regulator of pathogen defense in Arabidopsis, showing it affects resistance to bacterial and fungal pathogens through modulation of defense signaling and ROS scavenging.

This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.

The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.

This paper develops a photothermal nanoparticle conjugated with neutralizing antibodies to capture and inactivate SARS-CoV-2, showing efficient viral capture, photothermal effect, and inhibition of viral entry.

This study identifies RBM39's role in promoting PRRSV proliferation by altering c-Jun phosphorylation and binding viral RNA.

This study identifies altered small RNA modifications in Alzheimer's disease post-mortem samples compared to controls, with specific reductions in certain small RNA types.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

The paper shows sphingomyelinase disables Piezo1 channel inactivation, allowing sustained mechanical force response in vascular endothelial cells.